Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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Scalaran-type sesterterpenes from a Marine Sponge Smenospongia species showing the AMPK activation

  • Received : 2012.05.06
  • Accepted : 2012.06.08
  • Published : 2012.06.20
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Abstract

A new scalaran class sesterterpenoid with five known ones was isolated from a marine sponge Smenospongia species collected from the Gageo island, Korea. Chemical structure of all of compounds was determined on the basis of a combination of extensive 1D and 2D NMR experiments and MS data. The new compound exhibited a new functional group on a common scalaran sesterterpene skeleton, identified as 12-deacetoxy-23-deacetoxyscalarin. The compound 1 moderately showed the effect of the activation of AMP-activated protein kinase (AMPK) in L6 myoblast cell.

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References

  1. R.A. Keyzers, M.T. Davies-Coleman, Chem. Soc. Rev. 34, 355-365 (2005). https://doi.org/10.1039/b408600g
  2. G.R. Pettit, R. Tan, Z.A Cichaz, J. Nat. Prod. 67, 1767-1770 (2004). https://doi.org/10.1021/np0498354
  3. G. Ryu, S. Matsunaga, N. Fuseyani, J. Nat. Prod. 59, 515-517 (1998).
  4. L.C. Chang, S. Otero-Quintero, G.M. Nicholas, C.A. Breley, Tetrahedron 57, 5731-5738 (2001). https://doi.org/10.1016/S0040-4020(01)00515-4
  5. H. Kikuchi, Y. Tsukitani, I. Schimizu, M. Kobayashi, I. Kitagawa, Chem. Pharm. Bull, 31, 552-556 (1983). https://doi.org/10.1248/cpb.31.552
  6. P. Crews, P. Bescansa, J. Nat. Prod. 49, 1041-1052 (1986). https://doi.org/10.1021/np50048a012
  7. D.G. Hardie, S.A. Hawley, J.W. Scott, The Journal of Physiology 574, 7-15 (2006). https://doi.org/10.1113/jphysiol.2006.108944
  8. C. Barbara, et al, Cell Metabolism 3, 403-416 (2006). https://doi.org/10.1016/j.cmet.2006.05.005
  9. J.-R. Rho, H.-S. Lee, H. J. Shin, J.-W. Ahn, J.-Y. Kim, C.-J. Sim, J. Shin, J. Nat. Prod. 67, 1748-1751 (2004). https://doi.org/10.1021/np040103l
  10. J. Song, W. Jeong, N. Wang, H-S. Lee, C-J. Sim, K-B. Oh, J. Shin, J. Nat. Prod. 71, 1866-1871 (2008). https://doi.org/10.1021/np8003694