[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.6564/JKMRS.2012.16.1.001

Scalaran-type sesterterpenes from a Marine Sponge Smenospongia species showing the AMPK activation

Hwang, Buyng-Su (Department of Oceanography, Kunsan National University)
Rho, Jung-Rae (Department of Oceanography, Kunsan National University)

Publication Information

Journal of the Korean Magnetic Resonance Society / v.16, no.1, 2012 , pp. 1-10 More about this Journal

Abstract

A new scalaran class sesterterpenoid with five known ones was isolated from a marine sponge Smenospongia species collected from the Gageo island, Korea. Chemical structure of all of compounds was determined on the basis of a combination of extensive 1D and 2D NMR experiments and MS data. The new compound exhibited a new functional group on a common scalaran sesterterpene skeleton, identified as 12-deacetoxy-23-deacetoxyscalarin. The compound 1 moderately showed the effect of the activation of AMP-activated protein kinase (AMPK) in L6 myoblast cell.

Keywords

1D and 2D NMR; 12-deacetoxy-23-deacetoxyscalarin; sponge Smenospongia sp.; AMP-activated protein kinase (AMPK);

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