Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antibacterial Effect of Sohamhyung-tang Against Methicillin-Resistant Staphylococcus aureus

소함흉탕(小陷胸湯)의 Methicillin 내성 Staphylococcus aureus에 대한 항균활성 연구

  • Yum, Dae Yul (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Baek, Dong Ki (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Song, Yung Sun (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 염대열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 백동기 (원광대학교 한의과대학 내과학교실) ;
  • 송용선 (원광대학교 한의학전문대학원 제3의학과)
  • Received : 2012.11.25
  • Accepted : 2012.12.21
  • Published : 2012.12.25
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Abstract

Methicillin-Resistant Staphylococcus aureus (MRSA) is a cephalosporin and beta-lactam antibiotic-resistant strain. In most cases, MRSA is spread from infected patients and infection rates are growing increasingly. Furthermore, increased resistance to antibiotics is causing serious problems in the world. Staphylococcus aureus is responsible for both nosocomial and community-based infections that range from relatively minor skin and soft tissue infections to life-threatening systemic infections. Therefore, there is a need to develop alternative antimicrobial drugs for the treatment of infectious diseases. In this study, we investigated antimicrobial activity of oriental medicine prescription against MRSA. The minimum inhibitory concentration (MIC) of Sohamhyung-tang water extract against S. aureus strains ranged from 500 to 2,000 ${\mu}g/mL$, so we have it confirmed that a strong antibacterial effect. Also, the combinations of Sohamhyung-tang water extract and conventional antibiotics exhibited improved inhibition of MRSA with synergy effect. We suggest that Sohamhyung-tang water extract against MRSA have antibacterial activity, it has potential as alternatives to antibiotic agent. We suggest that the Sohamhyung-tang water extract lead the treatment of bacterial infection to solve the resistance and remaining side-effect problems that are the major weak points of traditional antibiotics.

Keywords

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