Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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A case of acute necrotizing encephalopathy associated with parainfluenza virus infection

  • Kim, Yoo-Na (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • You, Su-Jeong (Department of Pediatrics, Inje University Sanggye Paik Hospital)
  • 투고 : 2011.08.08
  • 심사 : 2011.11.14
  • 발행 : 2012.04.15
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초록

Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial neurologic sequelae. Here, we describe a case of a comatose 22-month-old girl who was admitted to our hospital because of febrile illness and seizures. On day 13 of her illness, she died from ANE associated with infection from parainfluenza virus. Brain MRI results indicated diffuse bilateral symmetric signal changes in both basal ganglia, thalami, periventricular white matter, pons, and cerebral white matter, as well as generalized swelling of the brain.

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참고문헌

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피인용 문헌

  1. Acute Necrotizing Encephalopathy: An Underrecognized Clinicoradiologic Disorder vol.2015, pp.None, 2012, https://doi.org/10.1155/2015/792578
  2. Severe acute encephalopathy related to human parainfluenza virus type 2 infection in an infant: a case report vol.2, pp.4, 2012, https://doi.org/10.1099/jmmcr.0.000072
  3. Acute Postviral Encephalopathy : Pathologic and Radiologic Correlation in an Atypical Case vol.3, pp.None, 2012, https://doi.org/10.1177/2329048x16658845
  4. Presentation and Outcome of Acute Necrotizing Encephalopathy of Childhood: A 10-Year Single-Center Retrospective Study From Hong Kong vol.35, pp.10, 2020, https://doi.org/10.1177/0883073820927915
  5. Multi-parametric magnetic resonance imaging in acute necrotizing encephalopathy of children: validity and prognostic value vol.51, pp.1, 2012, https://doi.org/10.1186/s43055-020-00214-1
  6. Influenza-Associated Encephalopathy and Acute Necrotizing Encephalopathy in Children: A Retrospective Single-Center Study vol.26, pp.None, 2021, https://doi.org/10.12659/msm.928374
  7. The landscape of extrapulmonary manifestations of human parainfluenza viruses: A systematic narrative review vol.65, pp.1, 2021, https://doi.org/10.1111/1348-0421.12865