Browse > Article
http://dx.doi.org/10.3345/kjp.2012.55.4.147

A case of acute necrotizing encephalopathy associated with parainfluenza virus infection  

Kim, Yoo-Na (Department of Pediatrics, Inje University Sanggye Paik Hospital)
You, Su-Jeong (Department of Pediatrics, Inje University Sanggye Paik Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.55, no.4, 2012 , pp. 147-150 More about this Journal
Abstract
Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial neurologic sequelae. Here, we describe a case of a comatose 22-month-old girl who was admitted to our hospital because of febrile illness and seizures. On day 13 of her illness, she died from ANE associated with infection from parainfluenza virus. Brain MRI results indicated diffuse bilateral symmetric signal changes in both basal ganglia, thalami, periventricular white matter, pons, and cerebral white matter, as well as generalized swelling of the brain.
Keywords
Acute necrotizing encephalopathy; Parainfluenza virus; Child;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mizuguchi M, Abe J, Mikkaichi K, Noma S, Yoshida K, Yamanaka T, et al. Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry 1995;58:555-61.   DOI   ScienceOn
2 Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 1997;19:81-92.   DOI   ScienceOn
3 Mastroyianni SD, Voudris KA, Katsarou E, Gionnis D, Mavromatis P, Vagiakou EA, et al. Acute necrotizing encephalopathy associated with parainfluenza virus in a Caucasian child. J Child Neurol 2003;18:570-2.   DOI   ScienceOn
4 Ravid S, Topper L, Eviatar L. Acute necrotizing encephalopathy presenting as a basal ganglia syndrome. J Child Neurol 2001;16:461-2.   DOI
5 Sazgar M, Robinson JL, Chan AK, Sinclair DB. Influenza B acute necrotizing encephalopathy: a case report and literature review. Pediatr Neurol 2003;28:396-9.   DOI   ScienceOn
6 Reed G, Jewett PH, Thompson J, Tollefson S, Wright PF. Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children < 5 years old. J Infect Dis 1997;175:807-13.   DOI   ScienceOn
7 Jackson MA, Olson LC, Burry VF. Parainfluenza virus and neurologic signs. Pediatr Infect Dis J 1994;13:759-60.   DOI   ScienceOn
8 McCarthy VP, Zimmerman AW, Miller CA. Central nervous system manifestations of parainfluenza virus type 3 infections in childhood. Pediatr Neurol 1990;6:197-201.   DOI   ScienceOn
9 Powell HC, Rosenberg RN, McKellar B. Reye's syndrome: isolation of parainfluenza virus. Report of three cases. Arch Neurol 1973;29:135-9.   DOI   ScienceOn
10 Voudris KA, Vagiakou EA, Skardoutsou A. Acute disseminated encephalomyelitis associated with parainfluenza virus infection of childhood. Brain Dev 2002;24:112-4.   DOI   ScienceOn
11 Ashtekar CS, Jaspan T, Thomas D, Weston V, Gayatri NA, Whitehouse WP. Acute bilateral thalamic necrosis in a child with Mycoplasma pneumoniae. Dev Med Child Neurol 2003;45:634-7.
12 Porto L, Lanferman H, Möller-Hartmann W, Jacobi G, Zanella F. Acute necrotising encephalopathy of childhood after exanthema subitum outside Japan or Taiwan. Neuroradiology 1999;41:732-4.   DOI   ScienceOn
13 Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, et al. Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin. Brain Dev 2009; 31:221-7.   DOI   ScienceOn
14 Munakata M, Kato R, Yokoyama H, Haginoya K, Tanaka Y, Kayaba J, et al. Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy. Brain Dev 2000;22:373-7.   DOI   ScienceOn