IMMUNE NETWORK

  • 제12권6호
  • /
  • Pages.277-283
  • /
  • 2012
  • /
  • 1598-2629(pISSN)
  • /
  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

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Vitamin C Up-regulates Expression of CD80, CD86 and MHC Class II on Dendritic Cell Line, DC-1 Via the Activation of p38 MAPK

  • Kim, Hyung Woo (School of Korean Medicine, Pusan National University) ;
  • Cho, Su In (School of Korean Medicine, Pusan National University) ;
  • Bae, Seyeon (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kim, Hyemin (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kim, Yejin (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Hwang, Young-Il (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Kang, Jae Seung (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine) ;
  • Lee, Wang Jae (Laboratory of Immunology and Vitamin C, Department of Anatomy, Seoul National University College of Medicine)
  • 투고 : 2012.11.27
  • 심사 : 2012.12.14
  • 발행 : 2012.12.31
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초록

Vitamin C is an essential water-soluble nutrient which primarily exerts its effect on host defense mechanisms and immune homeostasis, but the mechanism related to immune-potentiation is poorly understood. Since dendritic cells (DCs) are known as a potent antigen presenting cell (APC) that could enhance the antigen specific immune responses, we investigate the effects of vitamin C on activation of DCs and its related mechanism by using dendritic cell lines, DC-1. First, we found that there was no damage on DC-1 by 2.5 mM of vitamin C. In the presence of vitamin C, the expression of CD80, CD86, and MHC molecules was increased, but it was decreased by the pre-treatment of SB203580, p38 MAPK-specific inhibitor. We confirmed the phosphorylation of p38 MAPK was increased by the treatment of vitamin C. Taken together, these results suggest that vitamin C could enhance the activity of dendritic cells via the up-regulation of the expression of CD80, CD86, and MHC molecules and the activation of p38 MAPK is related to this process.

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과제정보

연구 과제 주관 기관 : Ministry of Health, Welfare & Family

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