한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제29권5호
  • /
  • Pages.400-403
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  • 2012
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

개에서 발생한 성호르몬 과다 분비와 관련된 비정형 부신피질기능 항진증

Atypical Cushing's Syndrome Associated with Sex Steroids Excess in a Dog

  • 김준환 (웨스턴 동물병원) ;
  • 홍연정 (웨스턴 동물병원) ;
  • 이현석 (전북대학교 수의과대학 및 생체안전성 연구소) ;
  • 박진호 (전북대학교 수의과대학 및 생체안전성 연구소) ;
  • 박철 (전북대학교 수의과대학 및 생체안전성 연구소)
  • Kim, Jun-Hwan (Western Animal Medical Center) ;
  • Hong, Yeon-Jung (Western Animal Medical Center) ;
  • Lee, Hyeon-Seok (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Park, Jin-Ho (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Park, Chul (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University)
  • 심사 : 2012.10.25
  • 발행 : 2012.10.31
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초록

10년령의 수컷 푸들이 복부팽만, 등쪽 몸통 부위 탈모, 간비대와 혈청 알칼리인산분해효소의 지속적인 상승으로 전북대학교 수의과대학 동물병원에 내원하였다. 간 생검 및 미세침흡인세포 검사법과 PAS 염색을 실시한 결과 공포성 간병증 및 간세포에 글리코겐이 침착된 것을 확인 하였다. ACTH 자극 시험 실시 전 후 코티솔 및 부신과 관련된 성 호르몬의 농도를 측정하였다. 측정결과 안드로스텐디온, 프로게스테론 및 수산화 프로게스테론의 상승을 관찰할 수 있었으며 코티솔농도는 정상 범위내에 존재하였다. 진단은 성호르몬과 관련된 비정형의 부신피질 기능 항진증으로 내렸으며 치료는 트릴로스탄으로 하였다. 치료 8주 후 등 부위의 탈모를 포함한 임상증상들이 개선되었다.

A 10-year-old, intact male, toy poodle was presented with abdominal distension, truncal alopecia, hepatomegaly, and sustained elevation of alkaline phosphatase. Vacuolar hepatopathy and glycogen deposition in hepatocytes were confirmed by liver biopsy and ultrasound-guided fine-needle aspiration with periodic acid-Schiff (PAS) staining of mass lesion respectively. Cortisol and some sex hormones associated with adrenal gland were analyzed at IDEXX Reference Laboratories before and 1 hour after ACTH stimulation. The results of analysis confirmed elevation of some sex hormones including androstenedione, progesterone and 17 hydroxyprogesterone, not cortisol concentration, before and 1 hour after ACTH stimulation. The dog was diagnosed as atypical form of hyperadrenocorticism associated with sex steroids excess. The treatment was initiated with trilostane (0.5 mg/kg, PO, q12hr) that is an adrenal steroid synthesis inhibitor. Trilostane was administered for 8 weeks and the clinical sign including truncal alopecia was improved.

키워드

참고문헌

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