• 대한수의학회지
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• 제59권4호
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• pp.223-226
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• 2019

A 7-year-old, spayed female Chihuahua with dyspnea, intermittent cyanosis, and dermal plaques was diagnosed with hyperadrenocorticism. Thoracic radiographs showed markedly hyperdense alveoli in multiple lung lobes. Computed tomography (CT) images showed lung mineralization confined to the lung parenchyma and pituitary macroadenoma. Pulmonary mineralization secondary to hyperadrenocorticism is commonly found on histopathologic examination. However, those lesions are rarely identified radiographically. We describe obvious pulmonary mineralization secondary to hyperadrenocorticism found on radiographs and present the first report regarding CT imaging of the mineralization. Pulmonary mineralization should be considered when a dog affected by hyperadrenocorticism shows diffuse lung mineralization on radiographs.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 춘계학술대회
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• pp.119-119
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• 2008

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 춘계학술대회
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• pp.120-120
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• 2008

• 한국임상수의학회지
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• 제19권4호
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• pp.455-460
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• 2002

Pituitary-dependent hyperadrenocorticism (PDH) was diagnosed with history taking, physical examination, complete blood count, serum chemistry profiles, abdominal radiology, ultrasonography and adrenal function tests in 3 dogs. Their clinical signs were polyuria, polydipsia, polyphagia, bilateral symmetrical truncal alopecia and secondary infection in skin or urinary tract. Especially one dog showed severe clinical signs such as calcinosis cutis and delayed wound healing. These 3 dogs were diagnosed as PDH, and treated with selegiline 1-2 mg/kg /ay sid PO. 2 dogs with clinical signs of PDH were disappeared and improved, but 1 dog with severe illness progressed gradually despite of selegiline and mitotane application, and eventually died.

• 한국임상수의학회지
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• 제25권6호
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• pp.476-481
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• 2008

A retrospective study of 17 dogs with hyperadrenocorticism (HAC) was performed to evaluate the clinical and clinicopathological outcomes in dogs with pituitary-dependent HAC or adrenal gland-dependent HAC. Sixteen dogs were monitored at day 10, 30 and 90 then every 3 month after first presentation. In each examination, physical examination and ACTH stimulation test and client questionnaire were performed. In 17 cases, eight dogs were successfully treated with mitotane therapy (median dose 16.7 mg/kg; range 5.3 to 50 mg/kg, SID); another one dog showed favorable response, but the clients declined to further treatment before the full control of the disease had been achieved; four dogs showed poor response to treatment. One dog was euthanized due to septicemia. These results showed canine HAC can be medically managed successfully without side effects at the doses used in this study.

• Journal of Veterinary Science
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• 제19권6호
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• pp.840-845
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• 2018

The purpose of this study was to propose a standard for differentiation between normal dogs and patients with hyperadrenocorticism (HAC) by measuring skin thickness via ultrasonography in small breed dogs. Significant changes in skin thickness of patients treated with prednisolone (PDS) or patients with HAC treated with trilostane were evaluated. Skin thickness was retrospectively measured on three abdominal digital images obtained from small breed dogs weighing < 15 kg that underwent abdominal ultrasonography. Mean skin thickness of normal dogs was $1.03{\pm}0.25mm$ (mean ${\pm}$ SD). Both the HAC and PDS groups showed significantly thinner skin than that in the normal group. Seven of the 10 HAC patients treated with trilostane had increased skin thickness. The area under the curve value of 0.807 was based on the receiver operating characteristics (ROC) curve for differentiating normal dogs from HAC patients. Sensitivity was 76% and specificity was 73% when skin thickness was less than the 0.83 mm cutoff value. In conclusion, measurement of skin thickness in small breed dogs by using ultrasonography is likely to provide clinical information useful in differentiating HAC patients from normal dogs. However, exposure to PDS, trilostane, and other conditions may have a significant effect on skin thickness.

• 대한수의학회지
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• 제55권3호
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• pp.205-208
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• 2015

Ten dogs were enrolled in this study: two healthy dogs, two obese dogs without other medical issues and six obese dogs with underlying diseases including pemphigus, chronic active hepatitis, hyperadrenocorticism, narcolepsy, otitis media and heartworm infection. Pyrosequencing of the 16S rRNA gene to explore the gut bacterial diversity revealed that distal gut bacterial communities of samples from patients with pemphigus, otitis media and narcolepsy consisted primarily of Firmicutes, while the major phylum of the distal gut bacterial communities in patients with chronic active hepatitis and hyperadrenocorticism was Fusobacteria. Proteobacteria were the dominant phylum in heartworm infected obese patients.

• 한국임상수의학회지
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• 제36권5호
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• pp.278-281
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• 2019

A 12-year-old castrated male Maltese dog was presented with a small-sized mass at the left fifth mammary gland. The dog had concurrent poorly responsive pruritus affecting the feet, pinnae, and trunk, a cystolith, and biliary sludge. Serum chemistry revealed elevated liver enzymes. The mammary gland mass was cytologically diagnosed as an early-stage mammary simple carcinoma and was surgically excised. Nine months after the diagnosis of the mammary carcinoma, hyperadrenocorticism was confirmed by adrenocorticotropic hormone stimulation test. This report describes the clinical signs, diagnostic imaging findings, and prognosis in a castrated male Maltese dog with mammary carcinoma.

• 한국임상수의학회지
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• 제31권3호
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• pp.233-236
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• 2014

피부염 치료를 위해 스테로이드를 처방받은 경력이 있는 11년령 수컷 시추가 비만, 얇은 피모, 복부 팽만으로 내원하였다. 방사선 사진상 폐야 전반에 기관지-간질패턴과 뚜렷한 흉막음영이 관찰되었으나 신체검사상 이와 관련한 증상은 보이지 않았다. 복부 초음파상 부신은 정상크기이며 간실질의 에코성 상승을 나타내었다. 컴퓨터 단층촬영상 폐 중앙부는 간유리음영을 나타내었으며 변연부는 중앙부에 비해 저감약성을 띄고, 고감약성 결절음영이 폐 실질전반에 산재되어 있었다. 영상진단학적 소견과 부신피질자극 호르몬 검사결과를 바탕으로 의인성 부신피질기능항진증과 속발성 폐 석회화로 진단하였다.

• 한국임상수의학회지
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• 제20권2호
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• pp.233-236
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• 2003

10년령의 중성화 되지 않은 암컷의 요크셔테리어가 건국대학교 부속 동물병원으로 진료가 의뢰되어 왔다. 환축은 얼굴과 복벽에 심각한 괴사성 피부염을 보였으며 또한 다음다뇨 및 다식증을 나타내었다. 병력청취와 신체검사, CBC, 혈액생화학 검사를 토대로 하여 부신피질기능항진증을 의심하였고, 나아가 ACTH 자극시험을 통하여 쿠싱증후 군이 확진되었다. 또한, High Dose Dexamethasone Suppression lest (HDDST)극 통하여 뇌하수체 의존성 부신피질 기능 항진증임을 알 수 있었다. Mitotane을 이용한 치료가 개시된후 심자한 피부문제와 PUPD등의 임상증상들이 개선되었다. 그 후 mitotane 처치가 적절히 이루어지고 잇는가를 검증하기 위해 ACTH의 추가적인 검사가 수행되었다. 이 임상증례는 심각한 피부문제를 가지고 있던 환축이 오진단되고 치료의 핵심을 찾지못해 1년 이상 지속된 환축이 mitotane을 이용하여 성공적으로 치료되어 유지되고 있음을 보여주는 증례이다.