Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Inhibited Rab11-FIP3 Expression on Membrane Trafficking of TRPV1 in Dorsal Root Ganglion of Rat

Rat의 후근 신경절 세포에서의 Rab11-FIP3 단백질 발현 저해가 TRPV1 채널의 세포막으로의 이동에 미치는 영향

  • Received : 2012.07.16
  • Accepted : 2012.08.15
  • Published : 2012.09.28
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Abstract

Not much is known about the membrane trafficking of TRPV1, a key player in pain transduction. Rab11-FIP3, which plays a role in various intracellular transportation pathways, has been reported to interact with TRPV1. In this study, in order to examine the role of Rab11-FIP3 in the membrane trafficking of TRPV1, Rab11-FIP3 expression in dorsal root ganglion (DRG) was inhibited using a siRNA technique. Transportation of TRPV1 to membranes was found to decrease when Rab11-FIP3 expression was inhibited, consistent with the results obtained with TRPV1-transfected HEK cells. Taken together, these results indicate that Rab11-FIP3 plays a role in the membrane trafficking of TRPV1.

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References

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