Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Growth Inhibitory Effect of (E)-2,4-bis(p-hydroxyphenyl)-2-Butenal Diacetate through Induction of Apoptotic Cell Death by Increasing DR3 Expression in Human Lung Cancer Cells

  • Lee, Ung-Soo (Department of Food Science & Technology, Korea National University of Transportation) ;
  • Ban, Jung Ok (College of Pharmacy, Medical Research Center, 3Chungbuk National University) ;
  • Yeon, Eung Tae (College of Pharmacy, Medical Research Center, 3Chungbuk National University) ;
  • Lee, Hee Pom (College of Pharmacy, Medical Research Center, 3Chungbuk National University) ;
  • Udumula, Venkatareddy (Department of Chemistry and Biochemistry, Brigham Young University) ;
  • Ham, Young Wan (Department of Chemistry, Utah Valley University) ;
  • Hong, Jin Tae (College of Pharmacy, Medical Research Center, 3Chungbuk National University)
  • Received : 2012.09.06
  • Accepted : 2012.11.14
  • Published : 2012.11.30
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Abstract

The Maillard Reaction Products (MRPs) are chemical compounds which have been known to be effective in chemoprevention. Death receptors (DR) play a central role in directing apoptosis in several cancer cells. In our previous study, we demonstrated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal, a MRP product, inhibited human colon cancer cell growth by inducing apoptosis via nuclear factor-${\kappa}B$ (NF-${\kappa}B$) inactivation and $G_2$/M phase cell cycle arrest. In this study, (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate, a new (E)-2,4-bis(p-hydroxyphenyl)-2-butenal derivative, was synthesized to improve their solubility and stability in water and then evaluated against NCI-H460 and A549 human lung cancer cells. (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate reduced the viability in both cell lines in a time and dose-dependent manner. We also found that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate increased apoptotic cell death through the upregulation of the expression of death receptor (DR)-3 and DR6 in both lung cancer cell lines. In addition to this, the transfection of DR3 siRNA diminished the growth inhibitory and apoptosis inducing effect of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate on lung cancer cells, however these effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate was not changed by DR6 siRNA. These results indicated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate inhibits human lung cancer cell growth via increasing apoptotic cell death by upregulation of the expression of DR3.

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