• 대한기계학회논문집A
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• 제25권6호
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• pp.1023-1030
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• 2001

The tensile properties of short nylon6 fiber reinforced NR and SBR have been investigated as functions of diameter ratio(DR), interphase condition, fiber aspect ratio(AR), and fiber content. The short-fiber(DR=3 and AR=2) reinforced SBR did not show the dilution effect for all interphase conditions. And the short-fiber(DR=3 and AR=2) reinforced NR did not show the dilution effect except for the no-coating. The better interphase condition, the lower dilution effect at same DR. The tensile moduli are significantly improved due to fiber content and diameter ratio at same interphase condition. The pull-out force increased with the DR. The better interphase condition, the higher pull-out force at same DR. It is found that the DR and AR have an important effect on tensile properties.

• Journal of Acupuncture Research
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• 제29권1호
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• pp.47-59
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• 2012

목적 : 이 연구는 봉독이 사람의 난소암 세포인 SKOV3와 PA-1에서 death receptor의 발현을 높여 세포자멸사를 촉진함으로써 암세포의 성장을 억제하는지 밝히고자 하였다. 방법 : 난소암의 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였으며, 세포자멸사 조절 단백질의 변동 관찰에는 western blot analysis를 시행하였고, 난소암 세포에서 death receptor의 변화를 관찰하기 위해 RT-PCR analysis를 시행하였다. 결과 : 1. DAPI, TUNEL staining assay 결과, 봉독은 투여량에 따라 세포자멸사의 유도를 통해 SKOV3와 PA-1 난소암세포의 증식을 억제하였고, 세포자멸사와 동반하여 DR4와 DR6의 발현이 두 암세포 모두에서 증가하였고, DR3의 출현은 PA-1 세포에서 증가하였다. 2. Death Receptor의 발현 증가에 따라 caspase-3, 8, 9 and Bax를 포함하는 세포자멸사 촉진 단백질의 발현이 동반하여 상승하였고 JAK2, STAT3의 인산화와 Bcl-2의 발현은 억제되었다. 3. siRNA 처리 시 봉독에 의한 DR3, DR4, DR6 발현증가와 STAT3의 활성억제가 역전되었다. 결론 : 이러한 결과는 봉독이 난소암 세포에서 DR3, DR4, DR6의 증가와 JAK2/STAT3 pathway의 억제를 통하여 세포자멸사를 유발한다는 것을 시사하며, 난소암의 예방과 치료에 효과적으로 활용될 수 있을 것으로 기대된다.

• 대한본초학회지
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• 제30권6호
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• pp.1-6
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• 2015

Objectives : Draconis Resina (DR), the resin of Daemonorops draco Bl., is used to circulate the blood and to stop bleeding. It also has been used to generate flesh including ulceration. The present study investigated the effects of DR extract on collagen metabolism in human fibroblasts and tyrosinase activity in mushroom tyrosinase.Methods : The effect of DR extract on type I procollagen production (collagen type I synthesis) and collagenase (matrix metalloproteinase-1, henceforth referred as MMP-1) activity in human normal fibroblasts cell line. Hs68 cells after ultraviolet B (UVB, 312 nm) irradiation was measured using the enzyme - linked immunosorbent assay (ELISA). The tyrosinase activity was also measured to find out the whitening effects in mushroom tyrosinase by ELISA method.Results : There was no cytotoxicity at DR extract at concentrations of 10 μg/ml, 30 μg/ml, and 100 μg/ml. DR extract significantly inhibited the increase of collagenase activity, whereas it did not show on the reduction of type I procollagen in UVB damaged Hs68 cells. DR extract did not reduce the L - DOPA oxidation. However, it significantly reduced the tyrosinase activity by DR extract at concentraions of 0.1 mg/ml, 1 mg/ml and 10 mg/ml.Conclusions : In conclusion, DR showed the anti-wrinkle and whitening effects via the inhibition of collagenase production and the tyrosinase activity. These results suggest that DR may have potential as an anti-aging ingredient in cosmetic herb markets.

• 설비공학논문집
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• 제28권11호
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• pp.450-457
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• 2016

While many studies on the heat transfer effect of an impinging jet have been published, most studies focus on the downward impinging jet. This study investigates the impinging jet heat transfer phenomenon when water at a temperature of $24^{\circ}C$ impinges on the downward isothermal circular plate at 60, 70, and $80^{\circ}C$ and when the upward round jet nozzle is 4, 6, and 8 mm diameter with a flow rate 3.6, 4.6, and 5.6 L/min, respectively, and when the ratio of the nozzle clearance/nozzle diameter (H/D) is 1. The results showed that, as the nozzle diameter decreases, the heat transfer coefficient increases at a constant flow rate. The correlation equation of $Nu_r$, $Pr_r$, and $Re_{jg}$ is obtained in the impinging and constant velocity flow region $(Nu_r/Pr^{0.4}_r)Dr=4.6[Re_{jg}(r/R_c)Dr]^{0.8}$ at all flow rates, in the deceleration and falling flow regions $(Nu_r/Pr^{0.4}_r)Dr=42.7{\mid}Re_{jg}(r/R_c)Dr-345.7{\mid}^{0.3}$ at 3.6 L/min, $(Nu_r/Pr^{0.4}_r)Dr=92.4{\mid}Re_{jg}(r/R_c)Dr-16.8{\mid}^{0.2}$ at 4.6 L/min, and $(Nu_r/Pr^{0.4}_r)Dr=322.4{\mid}Re_{jg}(r/R_c)Dr-536.2{\mid}^{0.01}$ at 5.6 L/min.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.785-790
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• 2013

Background: Persistent infection of one or more of about 15 high-risk human papillomaviruses (HR-HPVs), most commonly HPV types 16/18, has a significant role in cervical cancer initiation and progression. There are limited data available from north-east India about HPV prevalence though this region has high incidence rates of cervical cancer. The aim of this study was to investigate the HPV genotypes prevalent in cervical cancer patients of north-east India. Materials and Methods: We analyzed 107 cervical cancer patient samples. Nested multiplex PCR assays were employed for detection of 13 high risk and 5 low risk HPV types. Results: HPV was confirmed in 105 samples. The presence of 6 'carcinogenic' HPV types, HPV-16 (88%), -18 (15%), -31(4%),-45 (3%), -59 (4%), -58(1%), and one non carcinogenic, HPV-6/11 (6%), was recorded. Among various demographic and clinical factors only tumour stage showed a statistically significant association with HPV type infection (P=0.019). Conclusions: We suggest that the most prevalent genotype is HPV-16 followed by HPV-18 in cervical carcinoma patients of the north-eastern region of India. Advanced tumour stage may be associated with increased possibility of harbouring multiple HPV genotypes.

• 융합정보논문지
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• 제9권6호
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• pp.175-182
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• 2019

본 연구는 노인운전자용 자가 보고식 평가 SAFE-DR 개발 프로젝트의 일환으로 운전위험성 선별을 위한 기준점수를 확인하고 평가의 타당성을 검증하기 위해 수행되었다. Driver 65 Plus평가를 통해 노인운전자 132명을 58명의 위험성 운전자와 74명의 안전성 운전자로 구분하고, 이를 기준으로 SAFE-DR 평가의 위험성 예측 기준을 분석하였다. 또한 SAFE-DR 평가의 구성 타당도, 내용 타당도, 예측 타당도를 검증하였다. SAFE-DR 평가의 운전위험성 예측을 위한 기준점수는 74.5점으로 분석되었으며, 이 기준의 양성 예측도는 88.6%, 음성 예측도는 86.3%로 판별력은 훌륭한(excellent) 수준으로 확인되었다. 또한 집중타당성, 법칙타당성, 내용타당성이 적절한 것으로 판정되었다. 따라서 본 연구를 통해 SAFE-DR은 위험한 노인운전자를 선별하는 용도로 활용할 수 있는 적절한 평가임을 확인하였다.

• Journal of Electrical Engineering and Technology
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• 제13권6호
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• pp.2220-2226
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• 2018

Electric vehicles (EVs) are significant resources for demand response (DR). Thus, it is essential for EV aggregators to quantitatively evaluate their capability for DR. In this paper, a concept of dynamic equivalent battery (DEB) is proposed as a metric for evaluating the DR performance using EVs. The DEB is the available virtual battery for DR. The capacity of DEB is determined from stochastic calculation while satisfying the charging requirements of each EV, and it varies also with time. Further, a new indicator based on the DEB and time-varying electricity prices, named as value of DEB (VoDEB), is introduced to quantify the value of DEB coupled with the electricity prices. The effectiveness of the DEB and the VoDEB as metrics for the DR performance of EVs is verified with the simulations, where the difference of charging cost reduction between direct charging and optimized bidding methods is used to express the DR performance. The simulation results show that the proposed metrics accord well with the DR performance of an EV fleet. Thus, an EV aggregator may utilize the proposed concepts of DEB and VoDEB for designing an incentive scheme to EV users, who participate in a DR program.

• Journal of Chest Surgery
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• 제41권2호
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• pp.189-201
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• 2008

Dr. Schimert는 1918년 스위스에서 태어나고 항가리와 독일에서 의사 면허를 취득하였다. 세계 이차 대전 직후 미국으로 이민 후 인턴, 레지던트 트레이닝을 계속한 그는 1956년 당시 심장수술로 세계적 명성을 떨치고 있던 미네소타 대학의 Dr. Lillehei의 지도하에 심장수술 트레이닝을 시작하였다. 이 기간 중인 1958년 그는 당시 미네소타 프로젝트의 일원으로 한국의 서울대학병원에 근무를 시작하였다. 이후 15개월 동안 그는 의학 총괄 자문관으로서 전반적인 의학 교육 및 행정에 참여하는 한편 당시 초창기의 흉부외과를 정립시키는데 공헌하였다. 특히 1959년 8월 6일에는 심방중격결손 환자를 대상으로 심폐바이패스를 이용한 개심술을 시행하였으나 환자는 불행히도 수술 6시간 후에 사망하였다. Dr. Schimert는 1959년 10월 미국으로 귀국하여 이듬해인 1960년에는 뉴욕 Buffalo General Hospital의 첫 심장수술 책임자로 부임하였다. 이후 동 병원에서의 기여 및 성과를 인정받아 1985년에는 그를 기념하여 Dr. George Schimert Lectureship and Medical Conference가 제정되었다. 이후 은퇴 생활 중 2002년 12월 7일 병사하였다.

• 대한화학회지
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• 제55권6호
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• pp.936-939
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• 2011

Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권6호
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• pp.419-426
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• 2022

Topical anesthetics are routinely used in dental practice for various purposes. They are usually available at higher dosages and have serious potential adverse reactions, such as seizures, anaphylaxis, and acquired methemoglobinemia. To date, the scope of application of herbal plants and their extracts, which have medicinal properties, has been elaborated in the field of dentistry. The growing interest in herbal medication can be attributed to the increased safety profile of herbal agents, in contrast to synthetic preparations that have a higher risk of systemic complications. Herbal preparations can induce topical anesthesia with minimal side effects. Recently, many studies have reported the use of topical herbal preparations. The current review aimed to evaluate data from various articles comparing the capacity of herbal topical anesthetic formulations and conventional synthetic anesthetics in reducing pain perception when used as local anesthesia before dental procedures.