Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Synergic Effect of Quercetin and Astragalin from Mulberry Leaves on Ani-inflammation

상엽 유래 퀘세틴과 아스트라갈린의 항염증에 대한 상승효과

  • Mok, Ji-Ye (Department of Health Care & Science, College of Alternative Medicine, Jeonju University) ;
  • Jeong, Seung-Il (Jeonju Biomaterials Institute) ;
  • Kim, Jang-Ho (Jeonbuk Technopark) ;
  • Jang, Seon-Il (Department of Health Care & Science, College of Alternative Medicine, Jeonju University)
  • 목지예 (전주대학교 대체의학대학 건강관리) ;
  • 정승일 (전주생물소재연구소) ;
  • 김장호 (전북테크노파크) ;
  • 장선일 (전주대학교 대체의학대학 건강관리)
  • Received : 2011.08.22
  • Accepted : 2011.10.06
  • Published : 2011.10.25
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Abstract

The leaf of mulberry (Morus alba L) has long been used in Oriental medicine for the prevention or treatment of several diseases. However, little is known about the inhibitory effects of a single compound isolated from the mulberry leaves on inflammatory response. We are isolate a single compound of quercetin (3,3',4',5,7-pentahydroxyflavone) and astragalin (kaempferol-3-O-glucopyranoside) from the mulberry leaves, and then investigate the anti-inflammatory effects of quercetin, astragalin or quercetin plus astragalin in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. Each compound suppressed the production of inflammatory mediators (NO, $PGE_2$ and IL-6) in LPS-stimulated murine peritoneal macrophages in a dose-dependent manner. Especially, the cotreatment of quercetin (2.5 ${\mu}M$) and astragalin (2.5 ${\mu}M$) markedly suppressed the production and the expression of inflammatory mediators. These suppressive effects were synergistically increased by their combination. These results suggest that the combination of quercetin and astragalin from the mulberry leaves may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.

Keywords

References

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