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Synergic Effect of Quercetin and Astragalin from Mulberry Leaves on Ani-inflammation  

Mok, Ji-Ye (Department of Health Care & Science, College of Alternative Medicine, Jeonju University)
Jeong, Seung-Il (Jeonju Biomaterials Institute)
Kim, Jang-Ho (Jeonbuk Technopark)
Jang, Seon-Il (Department of Health Care & Science, College of Alternative Medicine, Jeonju University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.5, 2011 , pp. 830-836 More about this Journal
Abstract
The leaf of mulberry (Morus alba L) has long been used in Oriental medicine for the prevention or treatment of several diseases. However, little is known about the inhibitory effects of a single compound isolated from the mulberry leaves on inflammatory response. We are isolate a single compound of quercetin (3,3',4',5,7-pentahydroxyflavone) and astragalin (kaempferol-3-O-glucopyranoside) from the mulberry leaves, and then investigate the anti-inflammatory effects of quercetin, astragalin or quercetin plus astragalin in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. Each compound suppressed the production of inflammatory mediators (NO, $PGE_2$ and IL-6) in LPS-stimulated murine peritoneal macrophages in a dose-dependent manner. Especially, the cotreatment of quercetin (2.5 ${\mu}M$) and astragalin (2.5 ${\mu}M$) markedly suppressed the production and the expression of inflammatory mediators. These suppressive effects were synergistically increased by their combination. These results suggest that the combination of quercetin and astragalin from the mulberry leaves may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
Keywords
Mulberry(Morus alba L.) leaves; quercetin; astragalin; anti-inflammation; synergic effect;
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