Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Forsythiae Fructus and Its Active Component, Arctigenin, Provide Neuroprotection by Inhibiting Neuroinflammation

  • Park, Ji-Ho (Graduate School of East-West Medical Science, Kyung Hee University Global Campus) ;
  • Hong, Ye-Ji (Graduate School of East-West Medical Science, Kyung Hee University Global Campus) ;
  • Moon, Eun-Jung (Graduate School of East-West Medical Science, Kyung Hee University Global Campus) ;
  • Kim, Seul-A (Graduate School of East-West Medical Science, Kyung Hee University Global Campus) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
  • Received : 2011.06.03
  • Accepted : 2011.08.09
  • Published : 2011.10.30
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Abstract

In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinflammatory cytokines, interleukin $1{\beta}$, tumor necrosis factor ${\alpha}$ and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinflammation.

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References

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