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http://dx.doi.org/10.4062/biomolther.2011.19.4.425

Forsythiae Fructus and Its Active Component, Arctigenin, Provide Neuroprotection by Inhibiting Neuroinflammation  

Park, Ji-Ho (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Hong, Ye-Ji (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Moon, Eun-Jung (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Kim, Seul-A (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung Hee University Global Campus)
Publication Information
Biomolecules & Therapeutics / v.19, no.4, 2011 , pp. 425-430 More about this Journal
Abstract
In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinflammatory cytokines, interleukin $1{\beta}$, tumor necrosis factor ${\alpha}$ and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinflammation.
Keywords
Forsythiae fructus; Arctigenin; Microglia; Neuroprotection; Neuroinflammation;
Citations & Related Records
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