Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells

  • Hong, Sam-Yeol (Department of Molecular Bioscience, Institute of Bioscience and Biotechnology, College of Biomedical Science, Kangwon National University) ;
  • Cho, Jae-Youl (Department of Genetic Engineering, School of Life Science and Biotechnology, Sungkyunkwan University) ;
  • Seo, Dong-Wan (Department of Molecular Bioscience, Institute of Bioscience and Biotechnology, College of Biomedical Science, Kangwon National University)
  • Received : 2011.06.29
  • Accepted : 2011.08.09
  • Published : 2011.10.30
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Abstract

Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin derivative with anti-tumor activity. However, the biochemical and molecular mechanisms of G-Rp1 on anti-tumor activity are not fully understood. In the present study, we report that G-Rp1 inhibits lung cancer cell proliferation, migration and adhesion in p53 wild-type A549 and p53-defi cient H1299 cells. Anti-proliferative activity of G-Rp1 in lung cancer cells is mediated by enhanced nuclear localization of cyclin-dependent kinase inhibitors including $p27^{Kip1}$ and $p21^{WAF1/Cip1}$, and subsequent inhibition of pRb phosphorylation. We also show that these anti-tumor activities of G-Rp1 in both A549 and H1299 cells appear to be mediated by suppression of mitogenic signaling pathways such as ERK, Akt and $p70^{S6K}$. Taken together, these findings suggest further development and evaluation of G-Rp1 for the treatment of lung cancers with mutated p53 as well as wild-type p53.

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References

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