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http://dx.doi.org/10.4062/biomolther.2011.19.4.411

Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells  

Hong, Sam-Yeol (Department of Molecular Bioscience, Institute of Bioscience and Biotechnology, College of Biomedical Science, Kangwon National University)
Cho, Jae-Youl (Department of Genetic Engineering, School of Life Science and Biotechnology, Sungkyunkwan University)
Seo, Dong-Wan (Department of Molecular Bioscience, Institute of Bioscience and Biotechnology, College of Biomedical Science, Kangwon National University)
Publication Information
Biomolecules & Therapeutics / v.19, no.4, 2011 , pp. 411-418 More about this Journal
Abstract
Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin derivative with anti-tumor activity. However, the biochemical and molecular mechanisms of G-Rp1 on anti-tumor activity are not fully understood. In the present study, we report that G-Rp1 inhibits lung cancer cell proliferation, migration and adhesion in p53 wild-type A549 and p53-defi cient H1299 cells. Anti-proliferative activity of G-Rp1 in lung cancer cells is mediated by enhanced nuclear localization of cyclin-dependent kinase inhibitors including $p27^{Kip1}$ and $p21^{WAF1/Cip1}$, and subsequent inhibition of pRb phosphorylation. We also show that these anti-tumor activities of G-Rp1 in both A549 and H1299 cells appear to be mediated by suppression of mitogenic signaling pathways such as ERK, Akt and $p70^{S6K}$. Taken together, these findings suggest further development and evaluation of G-Rp1 for the treatment of lung cancers with mutated p53 as well as wild-type p53.
Keywords
Ginsenoside Rp1; Cell proliferation; Cell migration; p53; Lung cancer;
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