Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Right Caudate Volumetric Differences in Young Healthy Adults with Different Dopamine DRD2/ANKK1 Taq 1a Polymorphisms

정상 젊은 성인에서 도파민 DRD2/ANKK1 Taq 1a 유전자다형성에 따른 우측 미상핵 용적의 차이

  • Jeon, Yu-Jin (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Choi, Ye-Ra (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Ji-Hyun H. (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Jung, Ji-Young J. (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Da-Jung J. (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Yu, Suk-Gyeong (Department of Life Sciences, Ewha Womans University College of Natural Sciences) ;
  • Im, Joo-Yeon Jamie (Department of Life Sciences, Ewha Womans University College of Natural Sciences) ;
  • Lee, Jung-Hyun H. (Department of Psychiatry, Seoul National University College of Medicine)
  • 전유진 (서울대학교 의과대학 정신과학교실) ;
  • 최예라 (서울대학교 의과대학 정신과학교실) ;
  • 김지현 (이화여자대학교 생명과학부) ;
  • 정지영 (서울대학교 의과대학 정신과학교실) ;
  • 김다정 (서울대학교 의과대학 정신과학교실) ;
  • 유숙경 (이화여자대학교 생명과학부) ;
  • 임주연 (이화여자대학교 생명과학부) ;
  • 이정현 (서울대학교 의과대학 정신과학교실)
  • Received : 2011.09.01
  • Accepted : 2011.09.16
  • Published : 2011.11.30
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Abstract

Objectives The aim of this study was to assess variations in caudate volume according to dopamin receptor D2/ankyin repeat and kinase domain containing 1 (DRD2/ANKK1) Taq 1a polymorphisms in young healthy adults and to evaluate the relationship between caudate volumes and psychiatric symptoms as measured by the Brief Psychiatric Rating Scale. Methods Genetic information regarding DRD2/ANKK1 Taq 1a and T1-weighted brain magnetic resonance images were acquired from 30 young healthy adults. Automatic segmentation of caudate was performed using the FreeSurfer program. Results Individuals with A2 homozygotes of DRD2/ANKK1 Taq 1a polymorphisms (n = 10) had greater right caudate volumes compared to those with A1 allele (s)(18.4% greater ; p = 0.019). Right caudate volumes were negatively associated with total scores of the Brief Psychiatric Rating Scale (${\beta}$=-0.50 ; p = 0.016). Conclusions Our findings suggest the possibility that DRD2/ANKK1 Taq 1a polymorphisms may underlie the psychiatric symptoms by influencing the structure of the right caudate.

Keywords

References

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