Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Cistanche Deserticola on Thyroid Function in Hypothyroidism Rat Model Induced by PTU(6-Propyl, 2-thiouracil)

육종용이 PTU로 유발된 갑상선 기능저하증 동물모델에 미치는 영향

  • Lee, Seung-Jin (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Paik, Sun-Ho (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ahn, Se-Young (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Byung-Choel (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ahn, Young-Min (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 이승진 (경희대학교 한의과대학 신계내과학교실) ;
  • 백선호 (경희대학교 한의과대학 신계내과학교실) ;
  • 안세영 (경희대학교 한의과대학 신계내과학교실) ;
  • 이병철 (경희대학교 한의과대학 신계내과학교실) ;
  • 안영민 (경희대학교 한의과대학 신계내과학교실)
  • Received : 2011.09.28
  • Accepted : 2011.12.07
  • Published : 2011.12.25
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Abstract

Hypothyroidism is the most common disease in the endocrine system. Cistanche Deserticola has been used traditionally in the treatment of kidney deficiency and Yang deficiency syndrome. In this study, we investigated the therapeutic effects of Cistanche Deserticola on Hypothyroidism rat model induced by PTU. 24 Two-month-old Sprague-Dawley male rats were divided into 4 groups : 1) normal(n=6), 2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Cistanche Deserticola(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4 weeks. Cistanche Deserticola and levothyroxine was administered 2 weeks after PTU was initiated for a total duration of 2 week. Body weights were checked every week and after 4 weeks, biochemical analysis was performed and T3, T4 and TSH were measured by ELISA kits. In comparison with the normal group, the control group showed hypothyroidism with lower T3, T4 level and higher TSH level. In the Cistanche group the level of T4 was significantly increased and TSH level was significantly decreased. There was no significant difference in biochemical labs and weight between the Cistanche group and the control group. These findings suggest that Cistanche Deserticola could help the production of thyroid hormones under PTU suppression. And there is no harmful effect on liver and kidney function, and other metabolism. According to these results Cistanche Deserticola could be an useful agent for treating hypothyroidism.

Keywords

References

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