Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-Inflammatory Effect of Cornus Walteri

말채나무의 항염증 효과

  • Lee, Sang-Hyun (Department of Pharmaceutical Engineering, College of Health Sciences) ;
  • Yoon, Kwang-Ro (Department of Pharmaceutical Engineering, College of Health Sciences) ;
  • Lee, Eun (Department of Pharmaceutical Engineering, College of Health Sciences) ;
  • Cha, Yun-Yeop (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sangji University)
  • 이상현 (상지대학교 보건과학대학 제약공학과) ;
  • 윤광로 (상지대학교 보건과학대학 제약공학과) ;
  • 이은 (상지대학교 보건과학대학 제약공학과) ;
  • 차윤엽 (한의과대학 한방재활의학과)
  • Received : 2011.08.31
  • Accepted : 2011.11.01
  • Published : 2011.12.25
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Abstract

This research seeks a basis for developing new anti-inflammatory medicine by investigating Cornus Walteri extract for its anti-inflammatory effects. After the injection of LPS in to rats with Cornus Walteri extract, its anti-inflammatory effects were compared among the treatment groups. The plasma concentration of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ peaked at 5h after LPS injection, and the values of the Cornus Walteri extract groups were lower than those of the control group. In the increment of concentration of these cytokines at 2h and 5h after LPS injection, the Cornus Walteri groups were lower than that of control group. The plasma concentration of IL-10 peaked at 5h after LPS injection, and the values of the Cornus Walteri extract groups were higher than those of the control group. In the increment of cytokines concentration at 2h and 5h after LPS injection, the Cornus Walteri groups were higher than that of control group. Liver cytokines measurement was done at 5h after LPS injection. The concentration of liver IL-$1{\beta}$ and IL-6 in the Cornus Walteri groups was lower than that of the control group. The concentrations of liver TNF-${\alpha}$, and IL-10 showed no significant differences among all the treatment groups. In the studies of lipopolysaccharide-exposed Raw 264.7 cells, the concentration of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group). However, in lipopolysaccharide-exposed cells groups, they showed lower values than those of control group and these values showed a tendency to decrease in the Cornus Walteri groups. The concentration of IL-10 in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group), and among the lipopolysaccharide-exposed cells groups, all Cornus Walteri extract groups showed higher values than single lipopolysaccharide-exposed cells groups. This studies have shown that in vitro and in vivo Cornus Walteri extracts are significantly more sensitive to inflammatory cytokines and LPS induced lethality. We conclude that the Cornus Walteri extracts have an functional material for inflammatory activities.

Keywords

References

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