KSBB Journal

  • 제26권6호
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  • Pages.483-490
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  • 2011
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  • 1225-7117(pISSN)
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  • 2288-8268(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
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생리활성 펩타이드의 피부미용학적 특성 및 활용

Characteristics and Applications of Bioactive Peptides in Skin Care

  • 모상현 ((주)바이오에프디앤씨 생명과학연구소) ;
  • 정대현 ((주)바이오에프디앤씨 생명과학연구소) ;
  • 김형식 ((주)바이오에프디앤씨 생명과학연구소) ;
  • 조문진 ((주)바이오에프디앤씨 생명과학연구소) ;
  • 서효현 ((주)바이오에프디앤씨 생명과학연구소) ;
  • 김성준 (숙명여대 사회교육대학원 미용예술과)
  • Moh, Sang-Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.) ;
  • Jung, Dai-Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.) ;
  • Kim, Hyoung-Shik (Anti-aging Research Institute of BIO-FD&C Co., Ltd.) ;
  • Cho, Moon-Jin (Anti-aging Research Institute of BIO-FD&C Co., Ltd.) ;
  • Seo, Hyo-Hyun (Anti-aging Research Institute of BIO-FD&C Co., Ltd.) ;
  • Kim, Sung-Jun (Graduate School of Social Education, Sookmyung Women's University)
  • 투고 : 2011.11.28
  • 심사 : 2011.12.16
  • 발행 : 2011.12.31
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초록

Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloyl tetrapeptide-19 (DT-19) is stabilized by combining Lys-Glu-Cys-Gly with GA and nicotinoyl tripeptide-1 (NT-1) is synthesized by GHK and NA. According to experiments, CT-1 has an excellent anti-oxidant function even with a very small amount of 10 ppm CT-1. DT-19's tyrosinase inhibition activity has the better effect of about 28.57% in 0.01% and 33.33% in 0.005% of concentration and about 7.89% in 0.001% concentration than vitamin-C. In addition, NT-1 is safer than the NA. Almost BAPs like pal-KTTKS, acetyl hexapeptide, and copper tripeptide-1 have the anti-wrinkle effect while DT-19 and NT-1 are applicable for potential BAPs focused on the whitening effect. The three kinds of BAPs like CT-1, DT-19, and NT-1 consisting of amino acids are safe to the skin, and have more excellent stability than bio-materials which are found to be unstable and cause skin irritation. Due to the high biological activity of BAP in the field of skin care, its utilization will increase constantly.

키워드

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