Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Environmental Factors in Autism and Autistic Spectrum Disorder

자폐 스펙트럼장애의 환경 요인

  • Lim, Myung-Ho (Environmental Health Center, College of Medicine, Dankook University) ;
  • Kwon, Ho-Jang (Environmental Health Center, College of Medicine, Dankook University)
  • 임명호 (단국대학교 환경보건센터) ;
  • 권호장 (단국대학교 환경보건센터)
  • Received : 2010.09.09
  • Accepted : 2010.11.02
  • Published : 2011.03.31
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Abstract

Autism and autistic spectrum disorder are chronic neuro-developmental disorders characterized by social and language impairments and stereotyped, repetitive patterns of behavior. The etiology of autism remains unknown; however, a strong genetic component has been detected and environmental factors may also be involved in their etiologies. In the current study, we reviewed evidence for the presence of prenatal and perinatal factors, gastrointestinal factors, food allergies, metabolic and heavy metal factors, and other nutritional factors that may represent risk factors for the development of autism and autistic spectrum disorder.

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References

  1. Bailey A, Phillips W, Rutter M. Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatry 1996;37:89-126. https://doi.org/10.1111/j.1469-7610.1996.tb01381.x
  2. Fombonne E, Du Mazaubrun C, Cans C, Grandjean H. Autism and associated medical disorders in a French epidemiological survey. J Am Acad Child Adolesc Psychiatry 1997;36:1561-1569.
  3. Bertrand J, Mars A, Boyle C, Bove F, Yeargin-Allsopp M, Decoufle P. Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics 2001;108:1155-1161. https://doi.org/10.1542/peds.108.5.1155
  4. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 1995;25:63-77. https://doi.org/10.1017/S0033291700028099
  5. Smalley SL, Asarnow RF, Spence MA. Autism and genetics: a decade of research. Arch Gen Psychiatry 1988;45:953-961. https://doi.org/10.1001/archpsyc.1988.01800340081013
  6. Bristol MM, Cohen DJ, Costello EJ, Denckla M, Eckberg TJ, Kallen R, et al. State of the science in autism: report to the National Institutes Health. J Autism Dev Disord 1996;26:121-154. https://doi.org/10.1007/BF02172002
  7. Kolevzon A, Gross R, Reichenberg A. Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med 2007;161:326-333. https://doi.org/10.1001/archpedi.161.4.326
  8. Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, et al. Advancing paternal age and autism. Arch Gen Psychiatry 2006;63:1026-1032. https://doi.org/10.1001/archpsyc.63.9.1026
  9. Lauritsen MB, Pedersen CB, Mortensen PB. Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. J Child Psychol Psychiatry 2005;46:963-971. https://doi.org/10.1111/j.1469-7610.2004.00391.x
  10. Croen LA, Grether JK, Hoogstrate J, Selvin S. The changing prevalence of autism in California. J Autism Dev Disord 2002;32:207-215. https://doi.org/10.1023/A:1015453830880
  11. Croen LA, Grether JK, Selvin S. Descriptive epidemiology of autism in a California population: who is at risk? J Autism Dev Disord 2002;32:217-224. https://doi.org/10.1023/A:1015405914950
  12. Eaton WW, Mortensen PB, Thomsen PH, Frydenberg M. Obstetric complications and risk for severe psychopathology in childhood. J Autism Dev Disord 2001;31:279-285. https://doi.org/10.1023/A:1010743203048
  13. Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E, et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol 2005; 161:916-928. https://doi.org/10.1093/aje/kwi123
  14. Glasson EJ, Bower C, Petterson B, De Klerk N, Chaney G, Hallmayer JF. Perinatal factors and the development of autism: a population study. Arch Gen Psychiatry 2004;61:618-627. https://doi.org/10.1001/archpsyc.61.6.618
  15. Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology 2002;13:417-423. https://doi.org/10.1097/00001648-200207000-00009
  16. Torrente F, Ashwood P, Day R, Machado N, Furlano RI, Anthony A, et al. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry 2002;7:375-382. https://doi.org/10.1038/sj.mp.4001077
  17. Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT. Gastrointestinal abnormalities in children with autistic disorder. J Pediatr 1999;135:559-563. https://doi.org/10.1016/S0022-3476(99)70052-1
  18. Rosseneu S. Aerobic gut flora in children with autism spectrum disorder and gastrointestinal symptoms. Presented at: Deafeat Autism Now Conference. San Diego (CA), October 3, 2003.
  19. Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Vaisanen ML, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000;15:429-435. https://doi.org/10.1177/088307380001500701
  20. Weber W, Newmark S. Complementary and alternative medical therapies for attention-deficit/hyperactivity disorder and autism. Pediatr Clin North Am. 2007;54:983-1006. https://doi.org/10.1016/j.pcl.2007.09.006
  21. D'Eufemia P, Celli M, Finocchiaro R, Pacifico L, Viozzi L, Zaccagnini M, et al. Abnormal intestinal permeability in children with autism. Acta Paediatr 1996;85:1076-1079. https://doi.org/10.1111/j.1651-2227.1996.tb14220.x
  22. Horvath K, Perman JA. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep 2002;4:251-258. https://doi.org/10.1007/s11894-002-0071-6
  23. Levy SE, Hyman SL. Complementary and alternative medicine treatments for children with autism spectrum disorders. Child Ado-lesc Psychiatr Clin N Am 2008;17:803-820. https://doi.org/10.1016/j.chc.2008.06.004
  24. Knivsberg AM, Reichelt KL, Høien T, Nødland M. A randomised, controlled study of dietary intervention in autistic syndromes. Nutr Neurosci 2002;5:251. https://doi.org/10.1080/10284150290028945
  25. Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill L. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. J Autism Dev Disord 2006;36:413. https://doi.org/10.1007/s10803-006-0079-0
  26. Wolraich ML, Wilson DB, White JW. The effect of sugar on behavior or cognition in children. A meta-analysis. JAMA 1995;274: 1617-1621. https://doi.org/10.1001/jama.274.20.1617
  27. Lucarelli S, Frediani T, Zingoni AM, Ferruzzi F, Giardini O, Quintieri F, et al. Food allergy and infantile autism. Panminerva Med 1995;37:137-141.
  28. Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 2002;46:76-84. https://doi.org/10.1159/000065416
  29. Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK. Serum autoantibodies to brain in Landau-Kleffner variant, au-tism, and other neurologic disorders. J Pediatr 1999;134:607-613. https://doi.org/10.1016/S0022-3476(99)70248-9
  30. Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol 1997;17:88-90. https://doi.org/10.1016/S0887-8994(97)00045-3
  31. Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific autoantibodies in the plasma of subjects with autistic spec-trum disorder. Ann N Y Acad Sci 2007;1107:92-103. https://doi.org/10.1196/annals.1381.010
  32. Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a novel form of mercury poisoning. Med Hypotheses 2001;56:462-471. https://doi.org/10.1054/mehy.2000.1281
  33. Ng DK, Chan CH, Soo MT, Lee RS.. Low-level chronic mercury exposure in children and adolescents: meta-analysis. Pediatr Int 2007; 49:80-87. https://doi.org/10.1111/j.1442-200X.2007.02303.x
  34. Palmer RF, Blanchard S, Stein Z, Mandell D, Miller C. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place 2006;12:203-209. https://doi.org/10.1016/j.healthplace.2004.11.005
  35. DeStefano F. Vaccines and autism: evidence does not support a causal association. Clin Pharmacol Ther 2007;82:756. https://doi.org/10.1038/sj.clpt.6100407
  36. Hviid A. Postlicensure epidemiology of childhood vaccination: the Danish experience. Expert Rev Vaccines 2006;5:641-649. https://doi.org/10.1586/14760584.5.5.641
  37. Myers SM, Johnson CP. Management of children with autism spectrum disorders. Pediatrics 2007;120:1162-1182. https://doi.org/10.1542/peds.2007-2362
  38. Nye C, Brice A. Combined vitamin B6-magnesium treatment in autism spectrum disorder. Cochrane Database Syst Rev 2005:CD-003497.
  39. Ip P, Wong V, Ho M, Lee J, Wong W. Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol 2004;19:431-434. https://doi.org/10.1177/088307380401900606
  40. Adams JB, Romdalvik J, Ramanujam VM, Legator MS. Mercury, lead, and zinc in baby teeth of children with autism versus controls. J Toxicol Environ Health A 2007;70:1046-1051. https://doi.org/10.1080/15287390601172080
  41. Bradstreet J, Geier D, Dkartzinel J. a case control study of mercury burden in children with autistic spectrum disorders. J American Physics Surgeons 2003;8:76-79.
  42. Walsh W. Metallothionein and autism. Proceedings of the Defeat Autism now Conference; 2003 Oct 3; San Diego.
  43. Sliwinski S, Croonenberghs J, Christophe A, Deboutte D, Maes M. Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism? Neuro Endocrinol Lett 2006;27:465-471.
  44. Vancassel S, Durand G, Barthélémy C, Lejeune B, Martineau J, Guilloteau D, et al. Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids 2001;65:1-7. https://doi.org/10.1054/plef.2001.0281
  45. Patrik L, Salik R. The effect of essential fatty acid supplementation on language development and learning skills in autism and Asperger's syndrome. Autism Asperger's Digest 2005;36-37.
  46. Amminger GP, Berger GE, Schäfer MR, Klier C, Friedrich MH, Feucht M. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study. Biol Psychiatry 2007;61:551-553. https://doi.org/10.1016/j.biopsych.2006.05.007
  47. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004;80:1611-1617.
  48. Yorbik O, Sayal A, Akay C, Akbiyik DI, Sohmen T. Investigation of antioxidant enzymes in children with autistic disorder. Prostaglandins Leukot Essent Fatty Acids 2002;67:341-343. https://doi.org/10.1054/plef.2002.0439
  49. Kern JK, Jones AM. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B Crit Rev 2006;9:485. https://doi.org/10.1080/10937400600882079
  50. Pardo CA, Eberhart CG. The neurobiology of autism. Brain Pathol 2007;17:434-437. https://doi.org/10.1111/j.1750-3639.2007.00102.x
  51. McGinnis WR. Oxidative stress in autism. Altern Ther Health Med 2004;10:22-36.

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