Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antimicrobial Effects of the Extract of Galla rhois on the Long-term Swine Clinical Trial

양돈 임상 연구에 의한 천연물 오배자 추출물의 항균.항바이러스 효과 규명

  • Lee, Hyun-A (Center for Animal Resource Development, Wonkwang University) ;
  • Hong, Sun-Hwa (Institute of Animal Experiment & Efficacy Evaluation, Wonkwang University) ;
  • Han, Sang-Jun (Center for Animal Resource Development, Wonkwang University) ;
  • Kim, Ok-Jin (Center for Animal Resource Development, Wonkwang University)
  • 이현아 (원광대학교 동물자원개발연구센터) ;
  • 홍선화 (동물실험효능평가원) ;
  • 한상준 (원광대학교 동물자원개발연구센터) ;
  • 김옥진 (원광대학교 동물자원개발연구센터)
  • Accepted : 2011.01.28
  • Published : 2011.02.28
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Abstract

We are aim to evaluate antimicrobial effects of the extract of Galla rhois (GR) on the health status and performance of growing and finishing pigs. This study was conducted on the growing and finishing pigs (n = 200) for 130 days in a swine husbandry. The animals were divided with two groups; GR treated group (n = 100) and commercial diet feeding group (n = 100). GR treated animals had provided with commercial diet adding the extract of GR as 0.2%. During the study period, we compared clinical signs, weight increase rate, diet consumption amount, fecal scores, gross findings, necropsy findings, histopathological findings between the treated group and non treated group. After necropsy, bacteria isolation and PCR analysis were conducted with the clinical samples. As the results of this long-term clinical trial, GR showed the antimicrobial effects on respiratory disease and diarrhea. We were identified that GR had the anti-bacterial and anti-viral effects.

천연물 오배자 추출물은 in vitro 선행 연구를 통하여 병원성 세균과 바이러스에 대한 강력한 항균 항바이러스 효과를 확인하였다. 본 연구는 양돈 농장에서 130일간의 장기 임상시험을 통하여 효능평가를 통한 천연물 오배자 추출물의 항균 항바이러스 효과를 규명하고자 수행되었다. 200 마리의 돼지를 천연물 오배자 추출물 투여군과 비투여군으로 2 그룹으로 나누어 130일 동안 양돈농장에서 연구가 수행되었다. 천연물 오배자 추출물 투여군에는 항생제가 없는 사료에 천연물 오배자 추출물을 0.2% 배합하여 급여하였고 비투여군은 항생제가 포함된 일반 사료를 급여하였다. 연구기간 동안 사료섭취량, 체중, 임상증상을 분석하고 시험종료일에 부검하여 육안검사와 미생물학적 검사 및 병리조직학적 검사를 수행하였다. 연구결과 천연물 오배자 추출물은 양돈 산업에서 심각한 문제가 되고 있는 병원성 세균과 바이러스에 대한 강력한 항균 항바이러스 효과를 가지고 있는 것을 확인할 수 있었다.

Keywords

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