Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Drug Interaction of Warfarin with Simvastatin / Gemfibrozil : high levels of ALT/AST, rhabdomyolysis and acute renal failure

Warfarin과 Simvastatin/Gemfibrozil의 약물 상호 작용 : 높은 수치의 ALT/AST, 횡문근 융해와 급성 신장 장애

  • 윤현옥 (미국 하워드 대학교 약학대학) ;
  • Received : 2011.07.20
  • Accepted : 2011.08.11
  • Published : 2011.09.30
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Abstract

이 증례는 드물게 보는 경우로 simvastatin과 gemfibrozil을 오랫동안 함께 복용했음에도, 특이한 문제가 발현되지 않았지만, 이들을 warfarin와 함께 치료하는 경우, 아주 높은 alanine aminotransferase (ALT), aspartate aminotransferase(AST) 혈중 농도, rhabdomyolysis, 급성 신장 장애가 발생하였다. 그 후, Simvastatin와 gemfibrozil을 복용 중단시켰더니, ALT/AST는 빠르게 정상수치로 돌아온 경우이다. 이 증례 보고서는 의료인들에게 simvastatin과 gemfibrozil을 함께 혹은 따로 warfarin과 함께 복용시켜 치료할 경우, creatine phosphokinase (CPK) 와 creatinine 혈중 수치들을 포함하여 ALT/AST 농도들을 주의 깊게 모니터하도록 경각심을 주고자 한다.

Keywords

References

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