YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Sodium Metaarsenite (KML001) Induces G1 Phase Arrest in HCT116 Colorectal Cancer Cells

대장암 세포주에서 메타아비산 나트륨에 의한 G1 세포주기 정지

  • Hong, Yun-Kyung (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University) ;
  • Kim, Sun-Mi (Department of Physical Therapy, Graduate School of Inje University) ;
  • Lee, Seung-Hoon (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University) ;
  • Kang, Jae-Seon (Department of Pharmacy, College of Pharmacy, Kyungsung University) ;
  • Hong, Yong-Geun (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University)
  • 홍윤경 (인제대학교 대학원 재활과학과) ;
  • 김선미 (인제대학교 대학원 물리치료학과) ;
  • 이승훈 (인제대학교 대학원 재활과학과) ;
  • 강재선 (경성대학교 약학대학 약학과) ;
  • 홍용근 (인제대학교 대학원 재활과학과)
  • Received : 2011.08.04
  • Accepted : 2011.08.29
  • Published : 2011.10.31
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Abstract

KML001 reduced the proliferation of HCT116 cells in a concentration- and time-dependent manner without change of cell viability. Beclin-1 expression was significantly attenuated by KML001 (P<0.05), but no significant changes were observed in KML001-treated cells. The number of cells in G1 phase was increased 48 hr after KML001 treatment. Furthermore, a dramatic reduction in the frequency of beating and the number of embryoid bodies of the cells was noted after treatment. Taken together, KML001 suppresses the proliferation of HCT116 cells, which might be due to G1 phase arrest.

Keywords

References

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