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Sodium Metaarsenite (KML001) Induces G1 Phase Arrest in HCT116 Colorectal Cancer Cells  

Hong, Yun-Kyung (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University)
Kim, Sun-Mi (Department of Physical Therapy, Graduate School of Inje University)
Lee, Seung-Hoon (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University)
Kang, Jae-Seon (Department of Pharmacy, College of Pharmacy, Kyungsung University)
Hong, Yong-Geun (Department of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University)
Publication Information
YAKHAK HOEJI / v.55, no.5, 2011 , pp. 391-397 More about this Journal
Abstract
KML001 reduced the proliferation of HCT116 cells in a concentration- and time-dependent manner without change of cell viability. Beclin-1 expression was significantly attenuated by KML001 (P<0.05), but no significant changes were observed in KML001-treated cells. The number of cells in G1 phase was increased 48 hr after KML001 treatment. Furthermore, a dramatic reduction in the frequency of beating and the number of embryoid bodies of the cells was noted after treatment. Taken together, KML001 suppresses the proliferation of HCT116 cells, which might be due to G1 phase arrest.
Keywords
KML001; colorectal cancer cell; G1 phase arrest; cardiac toxicity;
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