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Wet SiO2 As a Suitable Media for Fast and Efficient Reduction of Carbonyl Compounds with NaBH3CN under Solvent-Free and Acid-Free Conditions

  • Kouhkan, Mehri (Department of Chemistry, Faculty of Science, Urmia University) ;
  • Zeynizadeh, Behzad (Department of Chemistry, Faculty of Science, Urmia University)
  • Received : 2010.06.28
  • Accepted : 2010.09.02
  • Published : 2010.10.20
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Abstract

Reduction of carbonyl compounds such as aldehydes, ketones, $\alpha,\beta$-unsaturated enals and enones, $\alpha$-diketones and acyloins was carried out readily with $NaBH_3CN$ in the presence of wet $SiO_2$ as a neutral media. The reactions were performed at solvent-free conditions in oil bath (70 - $80^{\circ}C$) or under microwave irradiation (240 W) to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.

Keywords

References

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