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http://dx.doi.org/10.5012/bkcs.2010.31.10.2961

Wet SiO2 As a Suitable Media for Fast and Efficient Reduction of Carbonyl Compounds with NaBH3CN under Solvent-Free and Acid-Free Conditions  

Kouhkan, Mehri (Department of Chemistry, Faculty of Science, Urmia University)
Zeynizadeh, Behzad (Department of Chemistry, Faculty of Science, Urmia University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.10, 2010 , pp. 2961-2966 More about this Journal
Abstract
Reduction of carbonyl compounds such as aldehydes, ketones, $\alpha,\beta$-unsaturated enals and enones, $\alpha$-diketones and acyloins was carried out readily with $NaBH_3CN$ in the presence of wet $SiO_2$ as a neutral media. The reactions were performed at solvent-free conditions in oil bath (70 - $80^{\circ}C$) or under microwave irradiation (240 W) to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.
Keywords
$NaBH_3CN$; Wet $SiO_2$; Solvent-free; Microwave irradiation; Reduction;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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