생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제17권4호
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  • Pages.203-209
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  • 2010
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

젊은 성인에서 위험 회피 기질과 우전두엽 및 좌두정엽과의 관련성 : 피질두께 분석

The Relationship between Harm Avoidance Temperament and Right Frontal and Left Parietal Lobes in Young Adults : A Cortical Thickness Analysis

  • 김다정 (서울대학교 자연과학대학 뇌과학협동과정) ;
  • 류영욱 (서울과학고등학교) ;
  • 박영준 (서울과학고등학교) ;
  • 안태주 (서울과학고등학교) ;
  • 최병주 (서울과학고등학교) ;
  • 신이경 (뉴욕대학교 화학과) ;
  • 김태석 (가톨릭대학교 의과대학 정신과학교실)
  • 투고 : 2010.07.01
  • 심사 : 2010.07.19
  • 발행 : 2010.11.30
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초록

Objectives : Increasing evidence suggests the presence of neurobiological bases for temperamental characteristics in humans. Brain correlates of harm avoidance(HA) have been most extensively studied using functional and structural brain imaging methods due to its potential link with anxiety and depressive disorders. To date, however, we are not aware of any reports that have examined the potential relationship between HA levels and regional cortical thickness. The aim of the current study is to examine the cortical thickness which is associated with HA temperament in healthy young subjects. Methods : Twenty-eight young, healthy individuals(13 men and 15 women, mean age, $29.4{\pm}6.3$ years) were screened for eligibility and administered the Korean version of the Cloninger's Temperament and Character Inventory and underwent high-resolution structural magnetic resonance imaging scanning. Results : HA was associated with cortical thickness in the right superior frontal cortex and in the left parietal cortex, adjusted for age and sex and corrected for multiple comparisons using the permutation testing method. Conclusion : Individual temperamental differences in HA are associated with structural variations in specific areas of the brain. The fact that these brain regions are involved in top-down modulations of subcortical fear reactions adds functional significance to current findings.

키워드

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