Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
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Abnormal Mismatch Negativity in Patients with Obsessive-Compulsive Disorder

강박증 환자에서의 Mismatch Negativity 이상에 관한 연구

  • Jang, Joon-Hwan (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Shin, Kyung-Soon (Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC) ;
  • Son, June-Hee (Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University) ;
  • Kwon, Jun-Soo (Department of Psychiatry, Seoul National University College of Medicine)
  • 장준환 (서울대학교 의과대학 정신과학교실) ;
  • 신경순 (서울대학교 의학연구원 신경과학연구소 임상인지신경과학센터) ;
  • 손준희 (서울대학교 자연과학대학 뇌인지과학과) ;
  • 권준수 (서울대학교 의과대학 정신과학교실)
  • Received : 2010.03.04
  • Accepted : 2010.04.08
  • Published : 2010.04.30
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Abstract

Objective : Mismatch negativity (MMN) provides an electrophysiological index of an involuntary attention switching process. This study investigated MMN anomalies and their relationship to clinical variables in patients with obsessive-compulsive disorder (OCD). Methods : Study participants were 29 OCD patients and 24 normal controls. We used a 128-channel EEG to measure MMN during a passive oddball paradigm. Then we assessed the correlations between MMN amplitudes and clinical measures. Results : The OCD patients exhibited significantly greater MMN amplitude compared to the controls. Also, the right frontal lobe MMN amplitudes correlated significantly to the OCD patients' Yale-Brown Obsessive Compulsive Scale total scores (r=-0.520, p=0.005). Conclusion : These results suggest that MMN anomalies in OCD patients reflect a monitoring circuit dysfunction, raising the possibility that the OCD's pathophysiology includes glutamatergic dysfunction.

Keywords

References

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