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왕겨초액의 추출물에 의한 아토피 완화 효과 비교

Analysis of Anti-Allergic Activities by Chaff Vinegar Liquor

  • 이상한 (경북대학교 식품생물산업연구소 및 식품공학과)
  • Lee, Sang-Han (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology, Kyungpook National University)
  • 투고 : 2010.02.04
  • 심사 : 2010.05.17
  • 발행 : 2010.06.30

초록

왕겨를 증류하여 생성된 왕겨초 증류액을 이용하여 접촉성 피부염에 어떤 영향이 있는지를 검토하였다. 왕겨초 증류액(2%)에 자소옆을 첨가한 샘플은 dinitrochlorobenzene에 의해 유발된 접촉성 피부염 질환 동물모델에서 피부상피조직의 비후정도를 약 20%정도의 수준으로 완화시키며, 이는 면역조직화학적인 방법으로 확인하였다. 이 결과로, 왕겨초 증류액은 아토피 완화 효과를 가지므로 이들의 적합한 조건을 확립한다면 향장소재 또는 이의 조성물로 유용하게 이용될 수 있다고 판단된다.

To evaluate whether chaff vinegar liquor (CVL) has potential in ameliorating allergic symptoms in mice, we tested the anti-allergic activities with a DNFB (dinitrofluorobenzene)-induced allergic mouse model. The DNFB-induced allergic symptoms were reduced by 20% compared to the control by chaff vinegar liquor supplemented with Perilla frutescens var. acuta. Allergic symptoms were examined by measuring the width of epidermis swelling. The hematoxyline & eosin (H&E) staining also revealed that the chaff vinegar liquor dramatically decreased the allergic symptoms in the epidermis of the ear. These results collectively suggest that the chaff vinegar liquor supplemented with P. frutescens var. acuta has potential in ameliorating allergic symptoms, showing that the liquor could be a useful biomaterial(s) for the nutraceutical or cosmetic industries.

키워드

참고문헌

  1. Bergstresser, P. R. 1989. Sensitization and elicitation of inflammation in contact dermatitis. Immunol. Ser. 46, 219-245.
  2. Falkeholm, L., C. A. Grant, A. Magnusson, and E. Moller. 2001. Xylene-free method for histological preparation: a multicentre evaluation. Lab Invest. 81, 1213-1221. https://doi.org/10.1038/labinvest.3780335
  3. Gantner, F., H. Tenor, V. Gekeler, C. Schudt, A. Wendel, and A. Hatzelmann. 1997. Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study. J. Allergy Clin. Immunol. 100, 527-535. https://doi.org/10.1016/S0091-6749(97)70146-5
  4. Heo, J. C., J. R. Rho, T. H. Kim, S. Y. Kim, and S. H. Lee. 2008. An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers. Int. J. Mol. Med. 22, 763-768.
  5. Hwang, Y. K., J. S. Chun, P. D. Yoo, J. Y. Ma, B. H. Hyun, S. U. Kim, K. T. Chang, and S. H. Lee. 2004. Occlusal reduction of unilateral molars influences change of stress-related hormones in rats. Scand. J. Lab. Animal Sci. 31, 73-77.
  6. Jorundsson, E., C. M. Press, M. Ulvund, and T. Landsverk. 1999. Prominence of gammadelta T cells in the elicitation phase of dinitrochlorobenzene-induced contact hypersensitivity in lambs. Vet. Pathol. 36, 42-50. https://doi.org/10.1354/vp.36-1-42
  7. Kimber, I., J. S. Pichowski, C. J. Betts, M. Cumberbatch, D. A. Basketter, and R. J. Dearman. 2001. Alternative approaches to the identification and characterization of chemical allergens. Toxicol. In Vitro 15, 307-312. https://doi.org/10.1016/S0887-2333(01)00027-3
  8. Meng, F., Y. Wei, and X. Yang. 2005. Iron content and bioavailability in rice. J. Trace Elem. Med. Biol. 18, 333-338. https://doi.org/10.1016/j.jtemb.2005.02.008
  9. Miller, J. S. and L. B. Schwartz. 1989. Human mast cell proteases and mast cell heterogeneity. Curr. Opin. Immunol. 1, 637-642. https://doi.org/10.1016/0952-7915(89)90033-2
  10. Morioka, Y., K. Yamasaki, D. Leung, and R. L. Gallo. 2008. Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis. J. Immunol. 181, 3915-3922. https://doi.org/10.4049/jimmunol.181.6.3915
  11. Pokharel, Y. R., S. C. Lim, S. C. Kim, T. H. Heo, H. K. Choi, and K. W. Kang. 2008. Sopungyangjae-tang inhibits development of dermatitis in Nc/Nga mice. Evid Based Complement Alternat Med. 5, 173-180. https://doi.org/10.1093/ecam/nem015
  12. Seo, Y. K., I. K. Lee, and S. H. Kim. 2009. Chaff-vinegar liquor exhibiting anti-allergic activities and compositions thereof. Korea Patent 10-0931529.
  13. Wuthrich, B. 1989. Epidemiology of the allergic diseases: are they really on the increase? Int. Arch. Allergy Appl. Immunol. 90, 3-10. https://doi.org/10.1159/000235067

피인용 문헌

  1. Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model vol.19, pp.5, 2012, https://doi.org/10.11002/kjfp.2012.19.5.792