Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effects of Baikal Skullcap (Scutellaria baicalensis Georgi) extracts on the recovery of liver function in $CCl_4$-exposed rats

황금 추출물이 $CCl_4$ 중독 쥐의 간장기능 회복에 미치는 영향

  • Lim, Sang-Cheol (Dept. of Horticulture and Landscape Architecture, Sangji University)
  • 임상철 (상지대학교 생명자원과학대학)
  • Received : 2009.12.28
  • Accepted : 2010.02.16
  • Published : 2010.02.28
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Abstract

The objective of present study was to investigate the effect of Baikal Skullcap (Scutellaria baicalensis Georgi) extracts on recovery of liver function in $CCl_4$-exposed rats. The values of RBC, Hb and PCV did not show significant difference among all treatment groups. The counts of WBC was lower in Skullcap extracts groups than in control group. The ratio of neutrophils and eosinophiles were decreased, and the ratio of lymphocytes and monocytes were increased with increased administration of Skullcap extracts dosage. The ratio of basophils was, however, not significantly different among all treatment groups. The concentration of plasma total protein and albumin showed no significant difference among all treatment groups. The ratio of albumin/globulin was higher in Skullcap extracts groups than in control group. The activities of GOT, GPT and LDH were lower in Skullcap extracts groups, compared to control group. The liver IL-$1{\beta}$, IL-6 and TNF-$\alpha$ concentration were decreased, and IL-10 was increased in Skullcap extract groups, compared to control group. Results of this study suggested that Skullcap may alleviate liver inflammatory reaction induced by liver toxicity.

황금추출물의 간장기능 회복능을 알아보기 위하여, $CCl_4$로 간중독을 유도한 쥐에게 황금추출물을 급여한 후, 혈액성상, 혈액 내 효소활성치 및 간장 내 전염증성 cytokines의 농도변화를 검토했다. RBC, Hb 및 PCV의 값은 처리군간에 유의한 차이를 나타내지 않았다. 백혈구 총수는 대조군과 비교하여 황금 처리군 모두가 낮은 수치를 나타내었으며, 황금추출물 첨가량이 증가함에 따라 neutrophils 및 eosinophile의 비율이 감소하고, lymphocytes 및 monocytes의 비율이 증가하였다. basophils의 구성비는 처리군 별 유의한 차이를 나타내지 않았다. Total protein 농도 및 albumin 농도는 처리군 간에 유의한 차이를 나타내지 않았다. 그러나 albumin/globulin 농도 비율은 대조군보다 황금추출물 처리군에서 높았다. GOT, GPT 및 LDH의 효소활성치들은 모두가 대조군보다 황금추출물 처리군에서 낮은 수치를 나타내었으며, 황금추출물 첨가량이 증가함에 따라 하락하는 경향을 보였다. 간장 내 IL-$1{\beta}$, IL-6 및 TNF-$\alpha$의 농도는 대조군보다 황금추출물 처리군 모두가 낮은 값을 나타내었으며, IL-10의 농도는 대조군보다 황금추출물 처리군 모두가 높은 값을 나타내었다. 이상의 결과를 종합해 보면 황금추출물은 간장기능회복에 효과를 나타내는 기능성 물질을 내재하고 있음을 시사해 준다.

Keywords

References

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