생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권1호
  • /
  • Pages.54-57
  • /
  • 2010
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

보골지와 염초보골지의 성분 정량 분석

Quantitative Analysis of Chemical Constituents in Psoraleae Semen and the Processed Psoraleae Semen

  • 김유진 (영남대학교 생명공학부) ;
  • 심상희 (영남대학교 생명공학부)
  • 투고 : 2010.01.23
  • 발행 : 2010.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A reversed phase HPLC method was developed to determine the major components of Psoralea corylifolia, psoralen, isopsoralen, bakuchiol, and corylin. Quantitative analysis of the above compounds was performed by C-18 column using a gradient solvent system of acetonitrile and water with UV detection at 310 nm. The comparison of contents of psoralen, isopsoralen, bakuchiol, and corylin in psoraleae semen and the processed psoraleae semen was also investigated. In result, processed psoraleae semen showed more amounts of psoralen, isopsoralen, and corylin with 1.6, 4.3, and 1.3 mg/g, respectively, except bakuchiol (66.98 mg/g) while psoraleae semen showed 0.53, 1.56, 1.0, and 76.3 mg/g of psoralen, isopsoralen, corylin, and bakuchiol, respectively.

키워드

참고문헌

  1. Jiangsu New Medical College (1985) Dictionary of Traditional Chinese Herbs, 1178. Shanghai Science and Technology Publishing House, Shanghai.
  2. Wang, S. (2006) Research survey of pharmacological effects of Fructus Psoraleae. Shizhen Guoyi Guoyao 17: 1081-1082.
  3. 신문농출판공가 (1995) 중약대사전, 2782. 일중사, 서울.
  4. Khastgir, H. N., Duttagupta, P. C. and Sengupta, P. (1961) The structure of psoralidin. Tetrahedron 14: 275-283. https://doi.org/10.1016/S0040-4020(01)92176-3
  5. Gupta, G. K., Dhar, K. L. and Atal, C. K. (1978) Corylinal: A new isoflavone from seeds of Psoralea corylifolia. Phytochemistry 17: 164. https://doi.org/10.1016/S0031-9422(00)89710-1
  6. Suri, J. L., Gupta, G. K., Dhar, K. L. and Atal, C. K. (1978) Psoralenol: A new isoflavone from the seeds of Psoralea corylifolia. Phytochemistry 17: 2046. https://doi.org/10.1016/S0031-9422(00)88771-3
  7. Mehta, G., Nayak, U. R. and Dev, S. (1973) Meroterpenoids: Psoralea corylifolia Linn.-l. Bakuchiol, a novel monoterpene phenol. Tetraheron 29: 1119-1125. https://doi.org/10.1016/0040-4020(73)80071-7
  8. Dong, N. T., Bae, K. H., Kim, Y. H., Hwang, G. S., Hwang, O. S., Kim, S. E. and Jong Seong Kang (2003) Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography. Arch. Pharm. Res. 26(7): 516-520. https://doi.org/10.1007/BF02976873
  9. Yang, B., Yai, S. and Cui, S. (1996) Comparison of ancient and modern processing methods for fructus Psoraleae, Zhongguo Zhong Yao Za Zhi 21(9): 537-539.
  10. Tan, S., Wang, Y., Liu, G., Guo, D. and Han, J. (1995) Determination of psoralen and isopsoralen in tincture of fructus Psoraleae by HPLC. Zhongguo Zhong Yao Za Zhi 20(2): 99-100.
  11. Kim, H. K., Lee, H. W., Chun, J. M., Lee, A. Y. and Ko, B. S. (2004) Quantitative Analysis of Psoralen and Angelicin in the Psoraleae Semen and Processed Psoraleae Semen. Kor. J. Pharmacogn. 35(3): 179-183.
  12. Kim, Y. J., Lee, H. Park, E. and Shim, S. H. (2009) Inhibition of Human 20S Proteasome by Compounds from Seeds of Psoralea corylifolia. Bull. Korean Chem. Soc. 30(8): 1867-1869. https://doi.org/10.5012/bkcs.2009.30.8.1867
  13. Shim, S. H. (2008) Proteasome Inhibition Activity of Psoraleae Semen and Processed Psoraleae Semen. Kor. J. Pharmacogn. 39(1): 56-59.