동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제21권4호
  • /
  • Pages.41-51
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  • 2010
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

사물탕, 사군자탕, 팔물탕, 십전대보탕의 약리 활성 비교 연구

Immuno stimulatory activities of Samul-tang, Sagunja-tang, Pamul-tang and Sipjeondaebo-tang in vitro

  • 이호영 (한국한의학 연구원 한약 EBM 연구센터) ;
  • 하혜경 (한국한의학 연구원 한약 EBM 연구센터) ;
  • 정다영 (한국한의학 연구원 한약 EBM 연구센터) ;
  • 이남헌 (한국한의학 연구원 한약 EBM 연구센터) ;
  • 신현규 (한국한의학 연구원 한약 EBM 연구센터)
  • Lee, Ho-Young (Herbal EBM reserach center. Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Herbal EBM reserach center. Korea Institute of Oriental Medicine) ;
  • Jung, Da-Young (Herbal EBM reserach center. Korea Institute of Oriental Medicine) ;
  • Lee, Nam-Hun (Herbal EBM reserach center. Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Herbal EBM reserach center. Korea Institute of Oriental Medicine)
  • 투고 : 2010.11.02
  • 심사 : 2010.12.06
  • 발행 : 2010.12.30
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초록

Objectives : Samul-tang(SM). Sagunja-tang(SG). Pamul-tang(PM) and Sipjeondaebo-tang(SJ) was used many diseases such as sterility. menstrual disorder. general prostration. recruitment in Korea. We investigated the immune stimulatory activities of SG. SM. PM and SJ in in vitro. Methods: For comparision for effective of SM. SG. PM and SJ. this study examined anti-inflammation(NO. PGE2 assay). anti-oxidation(DPPH assay) and immune response in in vitro assay. For immune response activities. this study used NO synthesis on RAW 264.7 cells, splenocyte proliferation and cytokine assay(IL-2, IL-4) in splenocyte. Results: The results showed that SG. SM. PM and SJ were no significant effect anti-oxidation and anti-inflammatory effects. For immune response. they showed the splenocyte proliferation and macrophage proliferation. We confirmed that they synthesised NO a dose-dependent manner significantly and secreted the IL-4. Conclusions : These results suggested the SG, SM, PM and SJ had immune stimulatory activity. A efficacy of immune response in them had produced similar results.

키워드

과제정보

연구 과제번호 : 표준한방처방 EBM 구축사업

연구 과제 주관 기관 : 한국한의학 연구원

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