부산지역 급성 호흡기 증상으로 외래 방문한 환자의 바이러스 원인과 역학: 2007-2008년

Viral Etiology and Epidemiology of Outpatients with Acute Respiratory Illnesses in Busan: 2007-2008

  • 정진우 (부산성모병원 소아청소년과) ;
  • 황윤하 (부산성모병원 소아청소년과) ;
  • 조경순 (부산보건환경연구원) ;
  • 정명주 (부산보건환경연구원) ;
  • 민상기 (부산보건환경연구원) ;
  • 김성준 (부산보건환경연구원) ;
  • 정우식 (부산성모병원 소아청소년과)
  • Jeong, Jin Woo (Department of Pediatrics, Busan St. Mary's Medical Center) ;
  • Hwang, Youn Ha (Department of Pediatrics, Busan St. Mary's Medical Center) ;
  • Cho, Kyung Soon (Busan Metropolitan City Institute of Health & Environment) ;
  • Jung, Myung Ju (Busan Metropolitan City Institute of Health & Environment) ;
  • Min, Sang Kee (Busan Metropolitan City Institute of Health & Environment) ;
  • Kim, Seong Joon (Busan Metropolitan City Institute of Health & Environment) ;
  • Chung, Woo Sik (Department of Pediatrics, Busan St. Mary's Medical Center)
  • 투고 : 2010.09.15
  • 심사 : 2010.10.19
  • 발행 : 2010.12.25

초록

목적 : 부산에서 급성호흡기 증상으로 외래 방문한 환자를 대상으로 원인 바이러스 및 역학을 연구하고자 하였다. 방법 : 2007년 1월부터 2008년 12월까지 3개 병원 소아청소년과 외래에 급성 호흡기 증상을 주소로 내원한 990명을 대상으로, 비강 세척법으로 검체를 채취하여 역전사중합효소연쇄반응을 시행하였다. 결과 : 총 검체 990건 중 351건(35.5%)이 검출되었으며, 남녀 비는 1.6대 1이었고, 5세 이하가 93.7%였다. hRV가 가장 흔한 원인으로 연중 202건(57.5%), 그 다음으로는 RSV로 10월부터 3월까지 57건(16.2%), ADV는 연중 37건(10.5%), INF는 12월부터 4월까지 21건(6%), hBoV는 1월부터 8월까지 15건(4.3%), PIV는 4월부터 7월까지 9건(2.6%), hCoV는 1월부터 7월까지 7건(2%), EV는 6월부터 9월에 3건(0.9%) 검출되었다. 결론 : 본 연구는 부산의 소아급성호흡기 질환을 예방하고 치료하는데 도움이 되고자 하며, 앞으로도 원인 바이러스에 대한 지속적인 연구가 필요하다.

Purpose : The purpose of this study is to identify the viral etiology of acute respiratory illnesses and to determine epidemiology in outpatients in Busan, Korea. Methods : We collected nasal wash samples from 990 patients who visited the hospital for acute respiratory illnesses between January 2007 and December 2008. Extracted DNA or RNA from specimens was used for viral detection by an RT-PCR method. Results : Of a total of 990 samples, viruses were detected in 351 cases (35.5%). The ratio of male to female was 1.6:1 and 93.7% were less than 5 years old. Rhinovirus was detected year-round in 202 cases (57.5%), respiratory syncytial virus from October to March in 57 cases (16.2%), adenovirus year-round in 37 cases (10.5%), influenza virus from December to April in 21 cases (6%), bocavirus from January to August in 15 cases (4.3%), parainfluenza virus from April to July in 9 cases (2.6%), coronavirus from January to July in 7 cases (2%), and enterovirus from June to September in 3 cases (0.9%). Conclusion : We identified the etiology and epidemiology of viruses that caused the acute respiratory diseases that were prevalent in Busan, 2007-2008. Further surveillance will be necessary.

키워드

참고문헌

  1. Denny FW. Clyde WA Jr. Acute lower respiratory tract infections in nonhospitalized childeren. J Pediatr 1986; 108:635-46. https://doi.org/10.1016/S0022-3476(86)81034-4
  2. Han MY, Lee BL, Seo WH, Ahn SH, Kim SJ, Hwang SJ, et al. Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infection and Analysis of Risk Factors in Severe Infections from 1995 to 2004. Pediatr Allergy Respir Dis(Korea) 2005;15:150-9.
  3. Chun JK, Lee JH, Kim HS, Cheong HM, Kim KS, Kang C, et al. Establishing a surveillance in Korean infants and young children. Eur J Clin Microbiol Infect Dis 2009;28:841-4. https://doi.org/10.1007/s10096-009-0701-0
  4. Ray CG, Holberg CJ, Minnich LL, Shehab ZM, Wright AL, Taussing LM. Acute lower respiratory illnesses during the first three years of life: potential roles for various etiologic agents. The Group Health Medical Associates. Pediatr Infect Dis J 1993;12:10-4. https://doi.org/10.1097/00006454-199301000-00004
  5. Acute respiratory infections in under-fives: 15 million deaths a year. Lancet 1985;2:699-701.
  6. Berman S, McIntosh K. Selective primary health care: strategies for control of disease in the developing world. XXI. Acute respiratory infections. Rev infect Dis 1985; 7:674-91. https://doi.org/10.1093/clinids/7.5.674
  7. Arnold JC, Singh KK, Spector SA, Sawyer MH. Human bocavirus: prevalence and clinical spectrum at a children's hospital. Clin Infect Dis 2006;43:283-8. https://doi.org/10.1086/505399
  8. Cho JI, Choi HC, Kim JD, Cho JH. The clinical study of the lower respiratory tract infections by respiratory syncytial virus on children under 2 year of age. Korean J Pediatr Infect Dis 2000;7:193-200.
  9. Yeom HH, Park JS, Jeong DJ, Kim CJ, Kim YB, Lee DH, et al. Human metapneumovirus infection in Korean children. Korean J Pediatr 2006;49:401-9. https://doi.org/10.3345/kjp.2006.49.4.401
  10. Lee WM, Grindle K, Pappas T, Marshall DJ, Moser MJ, Beaty EL, et al. High-throughput flow cytometry system for large-scale comprehensive detection of respiratory viruses. J Clin Microbiol 2007;45:2626-34. https://doi.org/10.1128/JCM.02501-06
  11. Kang YH, Lee DJ, Cho KS, Chung WS. Epidemiology of acute viral respiratory tract infections in Busan (2004- 2006). Korean J Pediatr Infect Dis 2007;14:179-87.
  12. Hazlett DT, Bell TM, Tukei PM, Ademba GR, Ochieng WO, Magana JM, et al. Viral etiology and epidemiology of acute respiratory infections in children in Nairobi, Kenya. Am J Trop Med Hyg 1988;39:632-40. https://doi.org/10.4269/ajtmh.1988.39.632
  13. Straliotto SM, Siqueira MM, Muller RL, Fischer GB, Cunha ML, Nestor SM. Viral etiology of acute respiratory infections among children in Porto Alegre, RS, Brazil. Rev Soc Bras Med Trop 2002;35:283-91. https://doi.org/10.1590/S0037-86822002000400002
  14. Lee SJ, Park EY, Oh PS, Lee KH, Kim KN, Lee KM. Viral Patterns and Clinical Analysis of Acute Respiratory Tract Infections of Children in Korea (September, 1998-August, 2002). Korean J Pediatr Infect Dis 2003;10: 102-13.
  15. Meerhoff TJ, Houben ML, Coenjaerts FE, Kimpen JL, Hofland RW, Schellevis F, et al. Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction. Eur J Clin Microbiol Infect Dis 2010;29:365-71. https://doi.org/10.1007/s10096-009-0865-7
  16. Han MY, Lee BL, SW H, Ahn SH, Kim SJ, Hwang SJ, et al. Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infection and Analysis of Risk Factors in Severe Infections from 1995 to 2004. Pediatr Allergy Respir Dis (Korea) 2005;15:150-9.
  17. Staat MA. Respiratory syncytial virus infections in children. Semin Respir Infect 2002;17:15-20. https://doi.org/10.1053/srin.2002.31688
  18. Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001;7:719-24. https://doi.org/10.1038/89098
  19. Mcintosh K. Rhinoviruses. In : Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: WB Saunders Co, 2007: 1395-6.
  20. Ruutu P, Halonen P, Meurman O, Torres C, Paladin F, Yamaoka K, et al. Viral lower respiratory tract infections in Filipino children. J Infect Dis 1990;161:175-9. https://doi.org/10.1093/infdis/161.2.175
  21. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004; 350:443-50. https://doi.org/10.1056/NEJMoa025472
  22. Bastin N, Brandt K, Dust K, Ward D, Li Y. Human Bocavirus Infection, Canada. Emerg Infect Dis 2006;12: 848-50. https://doi.org/10.3201/eid1205.051424
  23. Choi EH, Lee HJ, Kim SJ, Eun BW, Kim NH, Lee JA, et al. The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005. Clin Infect Dis 2006;43:585-92. https://doi.org/10.1086/506350
  24. Fry AM, Lu X, Chittaganpitch M, Peret T, Fischer J, Dowell SF et al. Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J Infect Dis 2007;195: 1038-45. https://doi.org/10.1086/512163
  25. Kahn J. Human bocavirus: clinical significance and implications. Curr Opin Pediatr 2008;20:62-6. https://doi.org/10.1097/MOP.0b013e3282f3f518
  26. Brieu N, Guyon G, Rodiere M, Segondy M, Foulongne V. Human bocavirus infection in children with respiratory tract disease. Pediatr Infect Dis J 2008;27:969-73. https://doi.org/10.1097/INF.0b013e31817acfaa
  27. Nelson D, Hiemstra H, Minor T, D'Alessio D. Non-polio enterovirus activity in Wisconsin based on a 20-year experience in a diagnostic virology laboratory. Am J Epidemiol 1979;109:352-61. https://doi.org/10.1093/oxfordjournals.aje.a112688