Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Efficacies of Sodium Carboxymethylcellulose, Oxidized Regenerated Cellulose and Vitamin E in Prevention Against Postoperative Adhesion Formation in Dogs

개에서 복강수술 후 유착방지에 대한 Sodium carboxymethylcellulose, Oxidized regenerated cellulose, Vitamin E의 효과

  • Kim, Jung-Eun (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Young-Sam (College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (College of Veterinary Medicine, Kyungpook National University)
  • Accepted : 2010.12.14
  • Published : 2010.12.31
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Abstract

This study was performed to compare the efficacy of the sodium carboxymethylcellulose (SCMC), oxidized regenerated cellulose (ORC), and their combination with vitamin E for the prevention of postoperative adhesions in the dog. Twenty five dogs were randomly divided into five groups ; non-treated group (Control Group), SCMC-treated group (SCMC Group), ORC-treated group (ORC Group), vitamin E and SCMC-treated group (SCMC + E Group), and vitamin E and ORC-treated group (ORC + E group). After laparotomy, 5 abrasions were made to induce intraperitoneal adhesions on the surface of the ileal serosa. The adhesions were occurred in serosa to mesentary (37.6%), serosa to serosa (24%), serosa to omentum (8.8%) and serosa to parietal peritoneum (3.2%). The incidences of adhesions were 92%, 84%, 64%, 56% and 68% in Control, SCMC, ORC, SCMC+E and ORC + E Group, respectively. The adhesion scores in SCMC+E Group were significantly lower than those in the other groups (p < 0.01). In conclusion, this study showed that oral supplements of vitamin E and intraperitoneal administration of 2% SCMC solution were effective on reducing intraperitoneal adhesions in the dog.

개에서 복강수술 후 유착방지에 대한 sodium carboxymethylcellulose (SCMC), oxidized regenerated cellulose (ORC), vitamin E의 병용효과를 알아보고자 본 실험을 수행하였다. 실험견은 대조군, SCMC 처치군, ORC 처치군, SCMC와 vitamin E 처치군, ORC와 vitamin E 처치군의 5개군으로 분류하고 각 군에 5두씩 배치하였다. 정중개복 후 회장 장막에 6 cm 간격으로 5곳에 찰과상을 입혀 유착을 유발했다. 유착장소는 전군에서 장막-장간막(37.6%), 장막-장막(24%), 장막-대망막(8.8%), 장막-복막(3.2%) 순으로 발생하였다. 유착발생빈도는 SCMC와 vitamin E 처치군이 56%로 대조군 92%, SCMC 처치군 84%, ORC 처치군 64%, ORC와 vitamin E 처치군 68%에 비해 낮았다. 유착형성 점수는 SCMC와 vitamin E 처치군에서 다른 처치군에 비해 유의적인 감소를 나타내었다(p < 0.01). 따라서, 복강수술 후 유착방지에 있어 SCMC와 vitamin E의 병용이 개에서 효과적이라고 생각된다.

Keywords

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