생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제17권3호
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  • Pages.127-135
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  • 2010
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

뇌 Single Photon Emission Computer Tomography 영상을 이용한 정신분열병 환자의 초기 증상 차이에 대한 연구

Comparative Study on Initial Symptoms Using Single Photon Emission Computer Tomography in Schizophrenia

  • 이진구 (충남대학교 의과대학 정신과학교실) ;
  • 김성민 (충남대학교 의과대학 핵의학교실) ;
  • 서영덕 (충남대학교 의과대학 핵의학교실) ;
  • 김기성 (락싸기술연구소) ;
  • 왕성근 (충남대학교 의과대학 정신과학교실) ;
  • 지익성 (충남대학교 의과대학 정신과학교실) ;
  • 김정란 (충남대학교 의과대학 정신과학교실)
  • Lee, Jin-Gu (Department of Psychiatry, School of Medicine, Chungnam National University) ;
  • Kim, Seong-Min (Department of Nuclear Medicine, School of Medicine, Chungnam National University) ;
  • Seo, Young-Duk (Department of Nuclear Medicine, School of Medicine, Chungnam National University) ;
  • Kim, Ki-Seong (Laxtha Institute of Technology) ;
  • Wang, Seong-Keun (Department of Psychiatry, School of Medicine, Chungnam National University) ;
  • Chee, Ik-Seung (Department of Psychiatry, School of Medicine, Chungnam National University) ;
  • Kim, Jeong-Lan (Department of Psychiatry, School of Medicine, Chungnam National University)
  • 투고 : 2010.04.26
  • 심사 : 2010.05.20
  • 발행 : 2010.08.31
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초록

Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

키워드

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