• Title/Summary/Keyword: $^{99m}Tc$-ECD PECT

Search Result 2, Processing Time 0.015 seconds

Comparative Study on Initial Symptoms Using Single Photon Emission Computer Tomography in Schizophrenia (뇌 Single Photon Emission Computer Tomography 영상을 이용한 정신분열병 환자의 초기 증상 차이에 대한 연구)

  • Lee, Jin-Gu;Kim, Seong-Min;Seo, Young-Duk;Kim, Ki-Seong;Wang, Seong-Keun;Chee, Ik-Seung;Kim, Jeong-Lan
    • Korean Journal of Biological Psychiatry
    • /
    • v.17 no.3
    • /
    • pp.127-135
    • /
    • 2010
  • Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

Crossed Cerebellar and Cerebral Cortical Diaschisis in Basal Ganglia Hemorrhage (기저핵 출혈에 의한 교차 소뇌 해리 현상)

  • Lim, Joon-Seok;Ryu, Young-Hoon;Kim, Hee-Joung;Lee, Byung-Hee;Kim, Byung-Moon;Lee, Jong-Doo
    • The Korean Journal of Nuclear Medicine
    • /
    • v.32 no.5
    • /
    • pp.397-402
    • /
    • 1998
  • Purpose: The purpose of this study was to evaluate the phenomenon of diaschisis in the cerebellum and cerebral cortex in patients with pure basal ganglia hemorrhage using cerebral blood flow SPECT. Materials and Methods: Twelve patients with pure basal ganglia hemorrhage were studied with Tc-99m ECD brain SPECT. Asymmetric index (AI) was calculated in the cerebellum and cerebral cortical regions as |$C_R-C_L$/$(C_R-C_L){\times}200$, where $C_R$and $C_L$ are the mean reconstructed counts for the right and left ROIs, respectively. Hypoperfusion was considered to be present when AI was greater than mean +2 SD of 20 control subjects. Results: Mean AI of the cerebellum and cerebral cortical regions in patients with pure basal ganglia hemorrhage was significantly higher than normal controls (p<0.05): Cerebellum ($18.68{\pm}8.94$ vs $4.35{\pm}0.94$, $mean{\pm}SD$), thalamus ($31.91{\pm}10.61$ vs $2.57{\pm}1.45$), basal ganglia ($35.94{\pm}16.15$ vs $4.34{\pm}2.08$), parietal ($18.94{\pm}10.69$ vs $3.24{\pm}0.87$), frontal ($13.60{\pm}10.5$ vs $4.02{\pm}2.04$) and temporal cortex ($15.92{\pm}11.95$ vs $5.13{\pm}1.69$). Ten of the 12 patients had significant hypoperfusion in the contralateral cerebellum. Hypoperfusion was also shown in the ipsilateral thalamus (n=12), ipsilateral parietal (n=12), frontal (n=6) and temporal cortex (n=10). Conclusion: Crossed cerebellar diaschisis (CCD) and cortical diaschisis may frequently occur in patients with pure basal ganglia hemorrhage, suggesting that CCD can develop without the interruption of corticopontocerebellar pathway.

  • PDF