Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Hepatic Detoxification and Antioxidant Activity in Sea-urchin Roe and Ethanol Extract of Roe

성게 부위별 및 그 추출물의 간 해독과 항산화 활성 효과

  • Lee, Seung-Joo (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Ha, Wang-Hyun (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Hye-Jin (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Cho, Soon-Yeong (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University)
  • 이승주 (강릉원주대학교 식품가공유통학과) ;
  • 하왕현 (강릉원주대학교 식품가공유통학과) ;
  • 최혜진 (강릉원주대학교 식품가공유통학과) ;
  • 조순영 (강릉원주대학교 식품가공유통학과) ;
  • 최종원 (경성대학교 약학대학)
  • Received : 2010.08.11
  • Accepted : 2010.10.04
  • Published : 2010.10.31
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Abstract

Sea-urchins (Anthocidaris crassispina) are widely distributed in the East Sea of Korea. The aim of this study was to evaluate the hepatoprotective effects of sea-urchin roe on bromobenzene (BB)-induced liver damage in rats. The antioxidative and detoxifying properties of sea-urchin roe in BB-poisoned rat liver was examined by chemical analysis of serum aminotransferase (AST, ALT), glutathione S-transferase (GST), $\gamma$-glutamylcystein synthetase, glutathione reductase, epoxide hydrolase, amino-N-demethylase (AD), aniline hydrolase (AH) enzyme activity, as well as lipid peroxide and glutathione contents. Sea-urchin roe inhibited the increase of serum AST, ALT enzyme activity. Increasing lipid peroxide contents and AD and AH activities were significantly decreased in ethanol extract of sea-urchin roe. GST, $\gamma$-glutamylcystein synthetase, glutathione reductase and epoxide hydrolase enzyme activities increased in sea-urchin roe-fed group, compared with the BB-treated group. These results suggest that sea-urchin roe facilitates recovery from liver damage by enhancing antioxidative defense mechanisms and hepatic detoxication metabolism.

Keywords

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