치위생과학회지 (Journal of dental hygiene science)

  • 제10권1호
  • /
  • Pages.25-29
  • /
  • 2010
  • /
  • 1598-4478(pISSN)
  • /
  • 2233-7679(eISSN)
한국치위생과학회 (The Korean Society of Dental Hygiene Science)
권호 표지

치주 질환 예방 및 치료용 소재로서 수종의 생약성분 추출물에 관한 항균, 항염, 항산화 효능 연구

Anti-microbial, Anti-inflammatory and Anti-oxidative Effects of Herbal Medicine Extracts as Anti-gingivitis Ingredients

  • 이동재 ((주)애경 중앙연구소 개인용품파트) ;
  • 한일민 ((주)애경 중앙연구소 개인용품파트) ;
  • 김우정 ((주)애경 중앙연구소 개인용품파트) ;
  • 조인식 ((주)애경 중앙연구소 개인용품파트)
  • Lee, Dong-Jae (Aekyung Central Research Laboratories Personal-care Products Part) ;
  • Han, Il-Min (Aekyung Central Research Laboratories Personal-care Products Part) ;
  • Kim, Woo-Jung (Aekyung Central Research Laboratories Personal-care Products Part) ;
  • Cho, In-Sik (Aekyung Central Research Laboratories Personal-care Products Part)
  • 투고 : 2009.12.24
  • 심사 : 2010.02.16
  • 발행 : 2010.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

치주질환의 예방 및 치료 효과를 연구하기 위해 수 종의 천연물을 이용하여 P. gingivalis에 대한 항균력과 IL-$1{\alpha}$ 생성 억제율을 평가하여 1차 선별한 후 MMP-1 활성 억제율 평가와 SOD 활성평가를 수행한 결과 다음과 같은 결론을 얻었다. 1. P. gingivalis에 대한 항균력 평가 결과 은행엽, 육두구, 대황, 후박, 구절초, 용아초, 목향, 세신, 산초, 회향 추출물에서 우수한 항균효과가 나타났다. 2. 인터루킨-$1{\alpha}$ (IL-$1{\alpha}$) 생성 억제율 평가 결과 은행엽, 작약, 육두구, 하고초, 후박, 과루, 산약 추출물이 우수한 IL-$1{\alpha}$ 생성 억제율을 나타내었다. 3. 매트릭스 메탈로프로테나제-1(MMP-1)의 활성 억제평가 결과, 육두구, 은행엽 추출물이 우수한 MMP-1 활성 억제율을 나타내었다. 4. 슈퍼록사이드 디스뮤타제 (Superoxide dismutase, SOD) 활성 평가 결과 은행엽, 산약, 육두구 추출물서 우수한 SOD 활성을 나타내었다. 5. 구강용 제품에 적용 시 은행엽 추출물은 우수한 잇몸질환 예방 및 치료 효능을 나타낼 수 있다.

This study was to estimate the effect of herbal medicines on periodontal disease. To screen effective materials for periodontal disease, we performed a series of test for 15 herbal medicine extracts. MIC test for P. gingivalis, IL-$1{\alpha}$ inhibition test, MMP-1 inhibition test and SOD activation test were carried out for herbal medicine extracts, respectively. The results are as followings : 1) Eunhang, Youkdoogu, Daewhang, Hoobak, Goojulcho, Yongacho, Mokhyang, Sesin, Sancho and Hoehyang extracts were effective for reduce P. gingivalis, 2) Eunhang, Jacyak, Youkdoogu, Hagocho, Hoobak, Guaru and Sanyak extracts showed high IL-$1{\alpha}$ inhibition rates, 3) Eunhang and Youkdoogu extracts have effects on MMP-1 inhibition, 4) Eunhang, Sanyak and Youkdoogu extracts effectively activate SOD. Especially, Eunhang extract has high performance through all estimations and can effectively prevent and treat periodontal disease.

키워드

참고문헌

  1. The Korean Association for Periodontal Research: Periodontal research, Seoul, pp. 116, 2004.
  2. Socransky SS et al.: Microbial complexes in subgingival plaque. J Clin Periodontol 25: 134-144, 1998. https://doi.org/10.1111/j.1600-051X.1998.tb02419.x
  3. Offenbacher S et al.: Periodontal disease at the biofilmgingival interface. J Periodontol 78(10): 1911-1925, 2007. https://doi.org/10.1902/jop.2007.060465
  4. Gurenlian, JoAnn R: The role of dental plaque biofilm in oral health. J Dent Hyg 81(5): 116, 2007.
  5. Jeng AY et al.: Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett 8: 897, 1998. https://doi.org/10.1016/S0960-894X(98)00142-5
  6. Emingil G et al.: The gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy. J Clin Periodontol 35(3): 221-229, 2008. https://doi.org/10.1111/j.1600-051X.2007.01192.x
  7. Sorsa T, Soumalainen K. Uitto VJ: The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal interstitial collagenase in human periodontal diseases. Arch Oral Biol 35: 193-196, 1990. https://doi.org/10.1016/0003-9969(90)90156-5
  8. Uitto VJ, Turto H. Saxen L: Extraction of collagenase from human gingival. J Periodont Res 12: 207-214, 1978.
  9. Jeon ES, Yoon SH, Han MD: Antimicrobial activity of Streptococcus mutans by herbal medicine extracts. J Dent Hyg Sci 2(1): 31-38, 2002.
  10. HJ Yoon et al.: Effects of medicinal plants against Streptococcus sobrinus B13 in hexane fraction. J Dent Hyg Sci 7(3): 197- 200, 2007.
  11. Kim CH et al.: Antimicrobial effect of Puerariae thunbergiana extracts against oral microorganism. J Dent Hyg Sci 4(1): 45- 48, 2004.
  12. Sreenivasan PK, Gaffar A: Antibacterials as anti-inflammatory agents. Dual action agents for oral health: Antonie Van Leeuwenhoek 93(3): 227-239, 2008.
  13. Noda D et al.: Relationship between the presence of periodontopathic bacteria and the expression of chemokine receptor mRNA in inflamed gingival tissues. J Periodontal Res 42(6): 566-571, 2007. https://doi.org/10.1111/j.1600-0765.2007.00984.x
  14. Katono T. et al.: Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts. Arch Oral Biol 54(2): 146-155, 2008.
  15. Pradeep AR et al.: Gingival crevicular fluid and plasma levels of neuropeptide Substance-P in periodontal health, disease and after nonsurgical therapy. J Periodontal Res 44(2): 232- 237, 2008.
  16. Dong Chen et al.: Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from porphyromonas gingivalis. Pharmacology 82(4): 264-269, 2008. https://doi.org/10.1159/000161127