Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Vanadium Water on Cancer-related Fatigue of Non Advanced Cancer Patients: Randomized Double Blinded Controlled Trial

비진행성 암환자의 암성 피로에 대한 바나듐수의 효능: 무작위배정 이중맹검 대조군 시험

  • Zheng, Hong-Mei (East-West Cancer Center, Dunsan Oriental Hospital) ;
  • Kim, Dong-Hee (Dept. of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Lee, Suk-Hoon (Dept. of Statistics, Chungnam National University) ;
  • Park, Yoo-Kyoung (Dept. of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital)
  • 정홍매 (대전대학교 둔산한방병원 동서암센터) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 이석훈 (충남대학교 통계학과) ;
  • 박유경 (경희대학교 동서의과학대학원 의학영양학과) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2010.08.23
  • Accepted : 2010.11.19
  • Published : 2010.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to evaluate the efficacy and safety of vanadium water (VW) on cancer-related fatigue of non-advanced cancer patients. For the experimental group administration, participants consumed three 500 mL/bottle bottles of Jeju Island's VW, which contained 15~20 ppb of vanadium, three times a day (morning, afternoon, evening) for 4 weeks (28 days) without any additional treatments for fatigue improvement. The control group participants consumed three 500 mL/bottle bottles of ordinary water (0 ppb of vanadium) three times a day for the same period of time without any additional treatments for fatigue improvement. After 4 weeks of VW consumption, total score of Revised Piper Fatigue Scale (RPFS) was reduced 30% compared to the basal score after Fisher's Exact Test which resulted in a statistical borderline significance (p=0.0799) and result of t-test of comparison between two groups' RPFS total score and fatigue cognitive/mood changes resulted in a statistical significance (p=0.0112). In detail, only 36.4% of control group (N=11) showed improvement while 77.8% of treatment group (N=9) showed fatigue improvement. No other lab measures, including thyroid hormone level indicated any significant differences between two groups. In conclusion, daily consumption of 1.5 L of vanadium water for 4 weeks showed improvement of non-advanced cancer patients' fatigue.

본 연구는 1일 1.5 L씩 4주간의 바나듐수 음용이 비진행성 암환자의 피로감 개선에 긍정적인 효과를 미치는 지 확인하기 위하여 수행되었다. 본 연구 결과 4주간의 바나듐수 음용은 비진행성 암환자의 피로감 개선을 위해 통계적으로 경계선상의 유의성을 보였으므로 향후에는 탐색형 연구로부터 확증형 연구를 통하여 피험자 수가 증가할 경우 통계학적으로 유의성을 보일 것이라고 예상되므로 근거 확보를 위한 진일보한 연구가 이루어져야 할 것이다. 즉 1일 1.5 L씩 4주간의 바나듐수 음용은 비진행성 암환자의 피로감 개선에 대해 유의수준 10%에서 통계적으로 유의한 차이가 나타났다. 이는 바나듐수가 암 환자의 피로에 도움이 되고 또한 참여자 수가 늘어날 경우 통계학적으로 유의성을 보일 것이라는 최소한의 근거를 보여주는 것이다. 향후에는 피험자수의 증가를 비롯하여 성별, 암종별 피험자수를 매치하고 피로감 개선을 포함한 기타 추가 기능에 대한 연구 수행을 기대할 수 있겠다.

Keywords

References

  1. Ahlberg K, Ekman T, Gaston-Johansson F, Mock V. 2003. Assessment and management of cancer-related fatigue in adults. Lancet 362: 640-650. https://doi.org/10.1016/S0140-6736(03)14186-4
  2. Kim DH. 2009. Excellence of Jeju volcanic bedrock water in eastern medical point of view. International Jeju Water Forum. p 123-137.
  3. Choi JY. 2008. Complementary therapy for improvement of quality of life in cancer patients. J Korean Med Assoc 41: 435-448.
  4. Jiang JF, Hao GL. 2004. Effect of the vanadium in nutrition.Feed Industry 25: 29-32.
  5. Smith DM, Pickering RM, Lewith GT. 2008. A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus. Q J Med 101: 351-358. https://doi.org/10.1093/qjmed/hcn003
  6. Lee NH, Hyun JW, Ji YH. 2009. Physiological function of Jeju water. International Jeju Water Forum. p 97-105.
  7. Piper BF, Dibble SL, Dodd MJ, Weiss MC, Slaughter RE,Paul SM. 1998. The revised Piper Fatigue Scale: psychometricevaluation in women with breast cancer. Oncol Nurs Forum 25: 677-684.
  8. Lee EH. 1999. Construct validity of the revised Piper Fatigue Scale in Korean women with breast cancer. J Korean Acad Nurs 29: 485-493. https://doi.org/10.4040/jkan.1999.29.3.485
  9. Kanfer EJ, Nicol BA. 1997. Haemoglobin concentration and erythrocyte sedimentation rate in primary care patients. J R Soc Med 90: 16-18.
  10. Pepys MB, Hirschfield GM. 2003. C-reactive protein: a critical update. J Clin Invest 111: 1805-1812. https://doi.org/10.1172/JCI200318921
  11. Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S. 2005. Adipokines: molecular links between obesity and atheroslcerosis.Am J Physiol Heart Circ Physiol 288: 2031-2041. https://doi.org/10.1152/ajpheart.01058.2004
  12. Kim ST, Kim YJ, Lee H, Choi SM, Yin C, Lee JY, Park HJ, Lee H. 2009. The effect of acupuncture for changing the levels of erythrocyte sedimentation rate, C-reactive protein and cytokines in the sera of rheumatoid arthritis patients. J ournal of Meridian & Acupoint 26: 27-38.
  13. Sato H. 2010. Clinical features of primary hyperthyroidism caused by Graves’ disease admixed with resistance to thyroid hormone (P453T). Endocrine J 57: 687-692. https://doi.org/10.1507/endocrj.K10E-066
  14. Kim SW. 2009. Sunitinib-induced hypothyroidism. Korean J Medicine 76: 33-36.
  15. Johnson JR, Temple R. 1985. Food and Drug Administration equirements for approval of new anticancer therapies. Cancer Treat Rep 69: 1155-1159.
  16. Lee EH, Park HB, Kim MO, Kang SH, Lee HJ, Lee WH,Chun MS. 2002. Analyses of the studies on cancer-relatedquality of life published in Korea. J Korean Soc TherapRadiol Oncol 20: 359-366.
  17. Buick DL, Petrie KJ, Booth R, Probert J, Benjamin C, Harvey V. 2000. Emotional and functional impact of radiotherapy and chemotherapy on patients with primary breast cancer. J Psychosoc Oncol 18: 39-62.
  18. Ahsberg E, Fürst CJ. 2001. Dimensions of fatigue during radiotherapy-an application of the swedish occupational fatigue inventory (SOFI) on cancer patients. Acta Oncol Acta Oncol : 37-43.
  19. Cho HS, Kim NH. 2010. Physical activity and fatigue in patients with cancer. J Korean Oncol Nurs 10: 30-37.
  20. Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA, Figueras C, Duane S, Mattar B, Liu H, Atherton PJ, Christensen B, Loprinzi CL. 2010. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation. Support Care Cancer 18: 179-187. https://doi.org/10.1007/s00520-009-0642-2
  21. Ansari MS, Gupta NP. 2004. Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol 22: 415-420. https://doi.org/10.1016/j.urolonc.2004.05.009
  22. Kienle GS, Kiene H. 2007. Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts. Eur J Med Res 12: 103-119.