Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Inhibitory Effect of quercetin-3-O-$\alpha$-L-rhamnopyranoside from Chamaecyparis obtuse on Aldose Reductase and Sorbitol Accumulation

백나무로부터 분리된 quercetin-3-O-$\alpha$-L-rhamnopyranoside의 알도스 환원효소 및 솔비톨 억제효과

  • Kim, Seon-Ha (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Kim, Jin-Kyu (Institute of Natural Medicine, Hallym University) ;
  • Lee, Yeon-Sil (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Bae, Young-Soo (Department of Forest Biomaterials Engineering, Kangwon National University) ;
  • Lim, Soon-Sung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
  • 김선하 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 김진규 (한림대학교 천연의약연구소) ;
  • 이연실 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 배영수 (강원대학교 산림바이오소재공학과) ;
  • 임순성 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터)
  • Received : 2010.08.03
  • Accepted : 2010.10.08
  • Published : 2010.10.30
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Abstract

Taxifolin-3-O-$\beta$-D-xylopyranoside and quercetin-3-O-$\alpha$-L-rhamnopyranoside were isolated from an EtOAc-soluble extract of the leaves of Chamaecyparis obtuse. Quercetin-3-O-$\alpha$-L-rhamnopyranoside was found to possess a potent inhibitory activity of human recombinant aldose reductase in vitro, its $IC_{50}$ value being $11.5\;{\mu}M$. Kinetic analysis showed that quercetin-3-O-$\alpha$-L-rhamnopyranoside exhibited uncompetitive inhibition against DL-glyceraldehyde. Also, quercetin-3-O-$\alpha$-L-rhamnopyranoside suppresses sorbitol accumulation in rat lens under high glucose conditions, demonstrating the potential to prevent sorbitol accumulation in vivo. These results suggest that this compound may be a promising agent in the prevention or treatment of diabetic complications.

Keywords

References

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