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Inhibitory Effect of quercetin-3-O-$\alpha$-L-rhamnopyranoside from Chamaecyparis obtuse on Aldose Reductase and Sorbitol Accumulation  

Kim, Seon-Ha (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Kim, Jin-Kyu (Institute of Natural Medicine, Hallym University)
Lee, Yeon-Sil (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Bae, Young-Soo (Department of Forest Biomaterials Engineering, Kangwon National University)
Lim, Soon-Sung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Publication Information
Korean Journal of Medicinal Crop Science / v.18, no.5, 2010 , pp. 305-310 More about this Journal
Abstract
Taxifolin-3-O-$\beta$-D-xylopyranoside and quercetin-3-O-$\alpha$-L-rhamnopyranoside were isolated from an EtOAc-soluble extract of the leaves of Chamaecyparis obtuse. Quercetin-3-O-$\alpha$-L-rhamnopyranoside was found to possess a potent inhibitory activity of human recombinant aldose reductase in vitro, its $IC_{50}$ value being $11.5\;{\mu}M$. Kinetic analysis showed that quercetin-3-O-$\alpha$-L-rhamnopyranoside exhibited uncompetitive inhibition against DL-glyceraldehyde. Also, quercetin-3-O-$\alpha$-L-rhamnopyranoside suppresses sorbitol accumulation in rat lens under high glucose conditions, demonstrating the potential to prevent sorbitol accumulation in vivo. These results suggest that this compound may be a promising agent in the prevention or treatment of diabetic complications.
Keywords
Chamaecyparis obtusa; Taxifolin-3-O-$\beta$-D-xylopyranoside; Quercetin-3-O-$\alpha$-L-rhamnopyranoside; Diabetic Complications; Human Recombinant Aldose Reductase; Sorbitol Accumulation;
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