Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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An Acetophenone Derivative, Clavatol, and a Benzodiazepine Alkaloid, Circumdatin A, from the Marine-Derived Fungus Cladosporium

  • Yang, Guohua (Department of Chemistry, Pukyong National University) ;
  • Nenkep, Viviane N. (Department of Chemistry, Pukyong National University) ;
  • Siwe, Xavier N. (Department of Chemistry, Pukyong National University) ;
  • Leutou, Alain S. (Department of Chemistry, Pukyong National University) ;
  • Feng, Zhile (Department of Chemistry, Pukyong National University) ;
  • Zhang, Dahai (Department of Chemistry, Pukyong National University) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Kang, Jung-Sook (College of Dentistry, Pusan National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2009.09.30
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Abstract

The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2',4'-dihydroxy-3',5'-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 $\mu$g/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED$_{50}$ values of 227.0 and 82.0 $\mu$M, respectively, indicating that they were more potent than the positive control, oxybenzone (ED$_{50}$ 350 $\mu$M), a common sunscreen agent.

Keywords

References

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