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An Acetophenone Derivative, Clavatol, and a Benzodiazepine Alkaloid, Circumdatin A, from the Marine-Derived Fungus Cladosporium  

Yang, Guohua (Department of Chemistry, Pukyong National University)
Nenkep, Viviane N. (Department of Chemistry, Pukyong National University)
Siwe, Xavier N. (Department of Chemistry, Pukyong National University)
Leutou, Alain S. (Department of Chemistry, Pukyong National University)
Feng, Zhile (Department of Chemistry, Pukyong National University)
Zhang, Dahai (Department of Chemistry, Pukyong National University)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Kang, Jung-Sook (College of Dentistry, Pusan National University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Natural Product Sciences / v.15, no.3, 2009 , pp. 130-133 More about this Journal
Abstract
The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2',4'-dihydroxy-3',5'-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 $\mu$g/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED$_{50}$ values of 227.0 and 82.0 $\mu$M, respectively, indicating that they were more potent than the positive control, oxybenzone (ED$_{50}$ 350 $\mu$M), a common sunscreen agent.
Keywords
Cladosporium sp.; Acetophenone; Clavatol; Benzodiazepine alkaloid; Circumdatin A;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 2
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