Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Forsythiaside, a Constituent of the Fruits of Forsythia suspense, Ameliorates Scopolamine-Induced Memory Impairment in Mice

  • Kim, Sun-Ho (Department of Life and Nanopharmaceutical Sciences) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences) ;
  • Choi, Ji-Joung (College of Pharmacy, Yeungnam University) ;
  • Lee, Jong-Gu (College of Pharmacy, Yeungnam University) ;
  • Lee, Choong-Ho (College of Pharmacy, Yeungnam University) ;
  • Park, Se-Jin (Department of Life and Nanopharmaceutical Sciences) ;
  • Jung, Won-Yong (Department of Life and Nanopharmaceutical Sciences) ;
  • Park, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences) ;
  • Ko, Kwang-Ho (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University) ;
  • Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Sciences)
  • Published : 2009.07.31
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Abstract

Forsythiaside is a polyphenolic constituent of the fruits of Forsythia suspense Vahl which are widely used as anti-inflammatory herbal raw materials in traditional Chinese medicine. In the present study, the authors assessed the effects of forsythiaside on learning and memory impairments induced by scopolamine using a passive avoidance and the Morris water maze tests in mice. Drug-induced amnesia was induced by scopolamine treatment (1 mg/kg, i.p.). Forsythiaside (10 mg/kg, p.o) administration significantly prevented scopolamine-induced step-through latency reduction in the passive avoidance test and scopolamine-induced increased escape latency in the Morris water maze test (p<0.05). Moreover, in an ex-vivo study, forsythiaside treatment (10 mg/kg, p.o) significantly reduced the increase of thiobarbituric acid reactive substance levels induced by scopolamine (p<0.05). Taken together, the present study suggests that forsythiaside could be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by its antioxidative properties.

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References

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