Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Methylsulfonylmethane on Hair Growth Promotion of Magnesium Ascorbyl Phosphate for the Treatment of Alopecia

  • Published : 2009.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to evaluate the effect of methylsulfonylmethane (MSM) on hair growth promotion of magnesium ascorbyl phosphate (MAP) for the treatment of alopecia. Aqueous solutions of MAP 7.5% with or without MSM 1%, 5% or 10% were prepared and applied onto the depilated back skin of the male mice once a day for 20 days. The degree of hair growth was evaluated by visual scoring using hair growth quantification scale (0-5, 0 being initial state and 5 being complete hair growth). In vitro transdermal penetration and intradermal retention studies of MAP were performed with Franz diffusion cell using hairless mice skin. Hair growth in the group treated with the aqueous solution containing MAP 7.5% and MSM 10% was comparable to or better than the result in the group treated with minoxidil 5% solution. Hair growth promotion of MAP was dose-dependently increased by the presence of MSM used in combination with MAP 7.5% solution. The in vitro transdermal penetration of the MAP was decreased in proportion to the concentration of MSM. However, intradermal retention of MAP was profoundly and dose-proportionally increased as a function of MSM concentration, reaching 802 ${\mu}g/cm^2$ in the presence of MSM 10% (200-fold increase). The effect of MSM on hair growth promotion of MAP was dose-proportional to the concentration of MSM due to the enhanced intradermal retention of MAP in the presence of MSM. Therefore, topical application of MAP together with MSM appears to be useful for the treatment of alopecia.

Keywords

References

  1. Abraham, M. H., Chadha, H. S. and Mitchell, R. C. (1995). The factors that influences skin penetration of solutes. J. Pharm. Pharmacol. 47, 8-16 https://doi.org/10.1111/j.2042-7158.1995.tb05725.x
  2. Ameye, L. G. and Chee, W. S. (2006). Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res. Ther. 8, R127 https://doi.org/10.1186/ar2016
  3. Asbill, C. S. and Michniak, B. B. (2000). Percutaneous penetration enhancers: local versus transdermal activity. PSTT 3, 36-41 https://doi.org/10.1016/S1461-5347(99)00225-4
  4. Barrager, E., Veltmann Jr. J. R., Schauss, A. G. and Schiller, R. N. (2002). A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J. Altern. Complement. Med. 8, 167-173 https://doi.org/10.1089/107555302317371451
  5. Blum, J. M. and Blum, R. I. (2004). The effect of methylsulfonylmethane (MSM) in the control of snoring. Integrative Medicine 3, 24-30
  6. Chen, C. H., Sheu, M. T., Wu, A. B., Lin, K. P. and Ho, H .O. (2005). Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model. Int. J. Pharm. 306, 91-98 https://doi.org/10.1016/j.ijpharm.2005.09.005
  7. Childs, S. J. (1994). Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis. Urol. Clin. North Am. 21, 85-88
  8. Clark, T., Murray, J. S. and Lane, P. (2008). Why are dimethyl sulfoxide and dimethyl sulfone such good solvents? J. Mol. Model 14, 689-697 https://doi.org/10.1007/s00894-008-0279-y
  9. Ellis, J. A., Sinclair, R. and Harrap, S. B. (2002). Androgenetic alopecia: pathogenesis and potential for therapy. Expert Rev. Mol. Med. 4, 1-11 https://doi.org/10.1017/S1462399402005112
  10. Engelen, V. H. W. and Engelen, V. P. A. (2002). Topical dermal anaesthetic. US Patent 6,416,772B1
  11. Franz, T. J., Lehman, P. A. and Kagy, M. K. (1995). Dimethyl sulfoxide. In Percutaneous Penetration Enhancers (E. W. Smith and H. I. Maibach, Eds.), pp.115-127. CRC Press, Boca Raton
  12. Godwin, D. A. and Michniak, B. B. (1999). Influence of drug lipophilicity on terpenes as transdermal penetration enhancers. Drug Dev. Ind. Pharm. 25, 905-915. https://doi.org/10.1081/DDC-100102251
  13. Hata, R. and Senoo, H. (1989). L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts. J. Cell Physiol. 138, 8-16 https://doi.org/10.1002/jcp.1041380103
  14. Im, T. J., Kang, M. J., Seo, D. W. and Lee, J. (2008). Effect of cubic liquid crystalline systems on skin localization of oregonin and hirsutanonol. Biomolecules & Therapeutics. 16, 226-230 https://doi.org/10.4062/biomolther.2008.16.3.226
  15. Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N. and Waters, R. F. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 14, 286-294 https://doi.org/10.1016/j.joca.2005.10.003
  16. Kim, N., El-Khalili, M., Henary, M. M., Strekowski, L. and Michniak, B. B. (1999). Percutaneous penetration enhancement activity of aromatic S, S-dimethyliminosulfuranes. Int. J. Pharm. 187, 219-229 https://doi.org/10.1016/S0378-5173(99)00194-5
  17. Paus, R. (2006). Therapeutic strategies for treating hair loss. Drug Discov. Today Ther. Strateg. 3, 101-110 https://doi.org/10.1016/j.ddstr.2006.03.004
  18. Pearson, T. W., Dawson, H. J. and Lackey, H. B. (1981). Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages. J. Agric. Food. Chem. 29, 1089-1091 https://doi.org/10.1021/jf00107a049
  19. Potts, R. O. and Guy, R. H. (1995). A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity. Pharm. Res. 12, 1628-1633 https://doi.org/10.1023/A:1016236932339
  20. Richmond, V. L. (1986). Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sciences 39, 263-268 https://doi.org/10.1016/0024-3205(86)90540-0
  21. Skelly, J., Shah, V., Maibach, H., Guy, R., Flynn, G. and Yacobi, A. (1987). FDA and AAPS report of the workshop on principles and practices of in vitro percutaneous penetration studies: relevance to bioavailability and bioequivalence. Pharm. Res. 4, 265-267 https://doi.org/10.1023/A:1016428716506
  22. Spiclin, P., Homar, M., Zupancic-Valant, A. and Gasperlin, M. (2002). Sodium ascorbyl phosphate in topical microemulsions. Int. J. Pharm. 256, 65-73 https://doi.org/10.1016/S0378-5173(03)00063-2
  23. Sung, Y. K., Hwang, S. Y., Cha, S. Y., Kim, S. R., Park, S. Y., Kim, M. K. and Kim, J. C. (2006). The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting vitamin C derivative. J. Dermatol. Sci. 41, 150-152. https://doi.org/10.1016/j.jdermsci.2005.11.010
  24. Takamizawa, S., Maehata, Y., Imai, K., Senoo, H., Sato, S. and Hata, R. (2004). Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells. Cell Biol. Int. 28, 255-265 https://doi.org/10.1016/j.cellbi.2004.01.010
  25. Trommer, H. and Neubert, R. H. (2006). Overcoming the stratum corneum: the modulation of skin penetration. Skin Pharmacol. Physiol. 19, 106-121 https://doi.org/10.1159/000091978
  26. Usha, P. R. and Naidu, M. U. (2004). Randomised, double-blind, parallel, placebo-controlled study of oral gGlucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin. Drug Investig. 24, 353-363
  27. Williams, A. C. and Barry, B. W. (1992). Skin absorption enhancers. Crit. Rev. Ther. Drug Carrier Syst. 9, 305-353
  28. Williams, A. C. and Barry, W. B. (2003). Penetration enhancers. Adv. Drug Deliv. Rev. 56, 603-618 https://doi.org/10.1016/j.addr.2003.10.025
  29. Yoo, J., Shanmugam, S., Song, C. K., Kim, D. D., Choi, H. G., Yong, C. S., Woo, J. S. and Yoo, B. K. (2008). Skin penetration and retention of L-ascorbic acid 2-phosphate using multilamellar vesicles. Arch. Pharm. Res. 31, 1652-1658 https://doi.org/10.1007/s12272-001-2164-4

Cited by

  1. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes vol.19, pp.2, 2009, https://doi.org/10.4062/biomolther.2011.19.2.231
  2. A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases vol.2021, pp.None, 2021, https://doi.org/10.1155/2021/6659943