Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Dipsaci Radix on Pain In Complex Region Pain Syndrome

실험적으로 유발한 복합부위통증증후군 모델에서 속단이 통증에 미치는 영향

  • Published : 2009.06.25
Download PDF
⟨ Previous Next ⟩

Abstract

It was reported that Dipsaci Radix has decrease pain effect on the Complex Region Pain Syndrome(CRPS). the CRPS was induced by unilateral loose occlusion in 4 part of the sciatic nerve of the rats. For the fingding significantly change on CRPS rats were divided into 4 different experimental groups. and each groups were induced CRPS. Experimental group I (control group; n=15), experimental group II (100 mg/kg Dipsaci Radix dieted rats; n=15), experimental group III (300 mg/kg Dipsaci Radix dieted rats; n=15), and experimental group IV(500 mg/kg Dipsaci Radix dieted rats; n=15). The study of Dipsaci Radix concentration was that foot withdrawal threshold to the thermal stimuli(Hot plate test), foot withdrawal threshold to the mechanical stimuli(von Frey's filament) and immunohistochemistry staining that were substance P. Hot plate test and von Frey Filament were increase in experimental group II, III, IV than group I, especially group III was most significantly change than group II and IV in post-hoc(Duncan's multiple range). and In immunohistochemistry observation; group I showed increase in the group II, III, IV. especially group III had the minimal level of the substance P expression while the experimental group II, III. These results suggested that the Dipsaci Radix dieted made the decrease of pain in CRPS.

Keywords

References

  1. vacariu, G. Complex regional pain syndrome. Disabil Rehabil 24(8):435-442, 2002 https://doi.org/10.1080/09638280110108869
  2. Janig, W., Baron, R. Experimental approach to CRPS. pain 108(1-2):3-7, 2004 https://doi.org/10.1016/j.pain.2004.01.005
  3. Turner-strokes, L. Reflex sympathetic dystrophy-a complex regional pain syndrome. Disabil Regabil. 24(18):939-947, 2002 https://doi.org/10.1080/0963828021000007950
  4. Bennett, G.J., Xie, Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. pain 33(1):87-107, 1988 https://doi.org/10.1016/0304-3959(88)90209-6
  5. Kurvers, H., Daemen, M., Slaaf, D., Stassen, F., van den Wildenberq, F., Kitslaar, P., de Mey, J. Partial peripheral neuropathy and denervation induced adrenoceptor supersensitivity-Functional studies in an experimental model. Acta Orthop Belg. 64(1):64-70, 1998
  6. Huygen, F.J., de Bruijn, A.G., Klein, J., Zijlstra, F.J. Neuroimmune alteration in the complex regional pain syndrome. EUR. J. Pharmacol. 429: 101-113, 2001 https://doi.org/10.1016/S0014-2999(01)01310-3
  7. 김호철. 한약약리학. 서울, 집문당, pp 420-450, 2001
  8. 안덕균, 최연수. 속단이 흰쥐의 난소적출로 유발한 골다공증에 미치는 영향. 본초학회지 9: 181-186, 1994
  9. 김강현, 전훈. 속단의 흰쥐장골 길이성장에 미치는 여향에 관한 연구. 동의생리병리학회지 15: 983-988, 2001
  10. 이영준,최희인,김윤철,신형식,유형근.속단의dichloromethane 분획물이 태아골모세포의 골형성 유도에 미치는 효과. 대한치주학회지 33: 259-269, 2003
  11. Hung, T.M., Na, M., Thuong, P.T., Su, N.D., Sok, D., Song, K.S., Seong, Y.H., Bae, K. Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall. J Ethnopharmacol. 108(2):188-192, 2006 https://doi.org/10.1016/j.jep.2006.04.029
  12. Li, D.Q., Li, Y., Liu, Y., Bao, Y.M., Hu, B., An, L.J. Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury. Toxicon 46(8):845-851, 2005 https://doi.org/10.1016/j.toxicon.2004.09.007
  13. 이황렬. 속단약침이 Adjuvant 관절염에 미치는 영향. 대전대학교 석사학위논문, 2000
  14. 진순용, 한영진, 최훈. 복합부위통증증후군 제1형으로 추정되는 상세불명의 흉부격통 치료 경험. 대한마취과학회지 47(5): 747-750, 2004
  15. Irintchev, A., Draguhn, A., Wernig, A. Reinnervation and recovery of mouse soleus muscle after long-term denervation. Neuroscience 39(1):231-243, 1990 https://doi.org/10.1016/0306-4522(90)90236-W
  16. Fu, S.Y., Gordon, T. Contributing factors to poor functional recovery after delayed nerve repair: prolonged axotomy. J Neurosci. 15: 3876-3885, 1995 https://doi.org/10.1523/JNEUROSCI.15-05-03876.1995
  17. Kingery, W.S., Davies, M.F., Clark, J.D. A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type Ⅱ. Pain 104: 75-84, 2003 https://doi.org/10.1016/S0304-3959(02)00467-0
  18. Seltzer, Z., Dubner, R., Shir, Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43: 205-218, 1990 https://doi.org/10.1016/0304-3959(90)91074-S
  19. Wasner, G., Schattschneider, J., Binder, A., Baron, R. Complex regional pain syndrome diagnostic, mechanisms, CNS involvement and therapy. Spinal Cord. 41: 61-75, 2003 https://doi.org/10.1038/sj.sc.3101404
  20. Urban, L., Thompson, S.W.N., Dray, A. Modulation of spinal excitability: cooperation between neurokinin and excitatory amino acids neurotransmitters. TINS. 17(10): 432-437, 1994 https://doi.org/10.1016/0166-2236(94)90018-3
  21. Kurvers, H.A., Jacobs, M.J., Beuk R.J., Van den wildenberg, F.A., Kitslaar, P.J., Slaaf, D.W., Reneman, R.S. Reflex sympathetic dystrophy ; evolution of microcirculatory disturbances in time. pain 60: 333-340, 1995 https://doi.org/10.1016/0304-3959(94)00133-Y
  22. Veldman, P.H., Reynen, H.M., Arntz, I.E., Goris, R.J. Signs and symptoms of reflex sympathetic dystrophy: prospctive study of 829 patients. Lancet 342: 1012-1016, 1993 https://doi.org/10.1016/0140-6736(93)92877-V
  23. 한국생약교수협의회. 본초학. 서울, 사단법인 대한 약사회, pp 755-758, 2002
  24. Garcia Leme, J., Hamamura, L. Formation of a factor increasing vascular permeability during electrical stimulation of the saphenous nerve in rats. Br. J. pharmacol. 51: 383-389, 1974 https://doi.org/10.1111/j.1476-5381.1974.tb10673.x
  25. Bowden, J.J., Garland, A.M., Baluk, P., Lefevre, P., Grady, E.F., Vigna, S.R., Bunnett, N.W., McDonald, D.M. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Natl Acad Sci USA. 91(19):8964-8968, 1994 https://doi.org/10.1073/pnas.91.19.8964
  26. Holzer, P., Jocic, M. Cutaneous vasodilatation induced by nitric oxide-evoked stimulation of afferent nerves in the rat. Br. J. Pharmacol. 112: 1181-1187, 1994 https://doi.org/10.1111/j.1476-5381.1994.tb13208.x
  27. Quartara, L., Maqqi, C.A. The tachykinin NK1 receptor. Part Ⅱ ; Distribution and pathophysiological roles. Neuropeptides 32(1):1-49, 1998 https://doi.org/10.1016/S0143-4179(98)90015-4