Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Influence of Water Soluble Polymers on Crystallization of 5-Guanosine Monophosphate

구아노신일인산의 결정화에 대한 수용성 고분자의 영향

  • Lee, Min-Kyung (Department of Chemical Engineering and Materials Science, Chung-Ang University) ;
  • Choi, Hye-Min (Department of Chemical Engineering and Materials Science, Chung-Ang University) ;
  • Kim, Woo-Sik (Department of Chemical Engineering, Kyunghee Univeisity) ;
  • Hong, Jong-Pal (KNDT&i Korea NonDestructive Testing Co., Ltd.) ;
  • Lee, Jong-Hwi (Department of Chemical Engineering and Materials Science, Chung-Ang University)
  • 이민경 (중앙대학교 공과대학 화학신소재공학부) ;
  • 최혜민 (중앙대학교 공과대학 화학신소재공학부) ;
  • 김우식 (경희대학교 공과대학 화학공학과) ;
  • 홍종팔 (케이엔디티앤아이(주) 기술연구소) ;
  • 이종휘 (중앙대학교 공과대학 화학신소재공학부)
  • Published : 2009.03.25
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Abstract

In presence of a polymer, the crystallization of low MW organic materials can be stopped at an intermediary step, where mesocrystals can be identified. A mesocrystal is defined as a superstructure of nanoparticles having polymer-adsorbed crystal faces on the scale of several hundred nanometers to micrometers. This study examined the effects of water soluble polymers and relevant parameters on the formation of guanosine-5'-monophosphate mesocrystals. It was observed in OM and SEM that GMP obtained in a polymer solution had a unique particle morphology different from the typical one of GMP. XRD analysis indicated that the polymer-directed crystallized GMP had a different polymorph of GMP. This result shows that the crystal structure of GMP can be changed by polymers. It was observed in TGA analysis that the polymer-directed crystallized GMP had a different water content, indicating a different type of hydrate.

고분자를 저분자 유기물질의 결정화 과정에 사용하면 결정형성과정을 중간 단계, 즉 메조크리스탈 단계에서 멈출 수 있다. 메조크리스탈은 수백 나노미터-수 마이크로미터의 결정들이 스스로 배열되어 결정성을 갖는, 결정과 고분자의 복합초구조로 정의할 수 있다. 본 연구에서는 구아노신일인산의 메조크리스탈 형성에서 고분자의 영향과 그와 관련된 변수들에 대해 알아 보았다. OM과 SEM 분석을 통해 고분자유도 결정화에 의한 GMP 결정은 전형적인 GMP입자와는 다른 모폴로지를 보임을 확인하였고, XRD 분석을 통해 새로운 polymorph를 가짐을 확인하였다. 이러한 결과는 고분자에 의해 GMP의 결정구조가 달라졌음을 의미하며, 결정 안에 함유되는 물의 함량이 달라져 다른 수화물 구조를 보임을 TGA 분석을 통해 확인하였다.

Keywords

References

  1. N. Jongen, P. Bowen, J. Lemaître, J. C. Valmaltette, and H. Hofmann, J. Colloid Interf. Sci., 226, 189 (2000) https://doi.org/10.1006/jcis.2000.6747
  2. A. Taden, K. Landfester, and M. Antonietti, Langmuir, 20, 957 (2004) https://doi.org/10.1021/la035723l
  3. H. Colfen and M. Antonietti, Angew. Chem. Int. Ed., 44, 5576 (2005) https://doi.org/10.1002/anie.200500496
  4. H. Colfen and S. Mann, Angew. Chem., 115, 2452 (2003) https://doi.org/10.1002/ange.200200562
  5. M. Antonietti, M. Breulmann, C. G. Goltner, H. Colfen, K. K. W. Wong, D. Walsh, and S. Mann, Chem. Eur. J., 4, 12 (1998)
  6. L. Zhou, D. Smyth-Boyle, and P. O’Brien, J. Am. Chem. Soc., 130, 1309 (2008) https://doi.org/10.1021/ja076187c
  7. A.-W. Xu, M. Antonietti, H. Colfen, and Y.-P. Fang, Adv. Funct. Mater., 16, 903 (2006) https://doi.org/10.1002/adfm.200500716
  8. J. Zhan, H.-P. Lin, and C.-Y. Mou, Adv. Mater., 15, 7 (2003)
  9. B. Judat and M. Kind, J. Colloid Interf. Sci., 269, 341 (2004) https://doi.org/10.1016/j.jcis.2003.07.047
  10. E. V. Shevchenko, D. V. Talapin, A. L. Rogach, A. Kornowski, M. Haase, and H. Weller, J. Am. Chem. Soc., 124, 11480 (2002) https://doi.org/10.1021/ja025976l
  11. D. Schwahn, Y. Ma, and H. C$\ddot{o}$lfen, J. Phys. Chem. C, 111, 8 (2007) https://doi.org/10.1021/jp068813i
  12. S. Wohlrab, H. Colfen, and M. Antonietti, Angew. Chem. Int. Ed., 44, 4087 (2005) https://doi.org/10.1002/anie.200462467
  13. S. Wohlrab, N. Pinna, M. Antonietti, and H. Colfen, Chem. Eur. J., 11, 2903 (2005) https://doi.org/10.1002/chem.200400420
  14. A. Kulkarni and C. Zukoski, J. Cryst. Growth, 232, 156 (2001) https://doi.org/10.1016/S0022-0248(01)01171-X
  15. A. L. Grzesiak and A. J. Matzger, J. Pharm. Sci., 96, 11 (2007) https://doi.org/10.1002/jps.20844
  16. C. P. Price, A. L. Grzesiak, and A. J. Matzger, J. Am. Chem. Soc., 127, 5512 (2005) https://doi.org/10.1021/ja042561m
  17. A. L. Grzesiak, F. J. Uribe, N. W. Ockwig, O. M. Yaghi, and A. J. Matzger, Angew. Chem. Int. Ed., 45, 2553 (2006) https://doi.org/10.1002/anie.200504312
  18. I. D. Morrison and S. Ross, Colloidal Dispersion: Suspension, Emulsion, Foams, Willey-Interscience, New York, 2002
  19. T. Uemura, Y. Hoshino, S. Kitagawa, K. Yoshida, and S. Isoda, Chem. Mater., 18, 4 (2006) https://doi.org/10.1021/cm0525353
  20. P. C. Ohara, D. V. Leff, J. R. Heath, and W. M. Gelbart, J. Phys. Chem., 99, 7036 (1995) https://doi.org/10.1021/j100018a041
  21. T. Uemura and S. Kitagawq, J. Am. Chem. Soc., 125, 7814 (2003) https://doi.org/10.1021/ja0356582
  22. T. Uemura, M. Ohba, and S. Kitagawa, Inorg. Chem., 43, 7339 (2004) https://doi.org/10.1021/ic0488435
  23. J. W. Mullin, Crystallization, Butterworths-Heinemann, Oxford, Vol 121, p 175 (1993)
  24. J. T. Carstensen, Advanced Pharmaceutical Solids, Marcel Dekker, New York, p 100 (2001)
  25. L. A. Gower and D. A. Tirrell, Journal of Crystal Growth, 191, 153 (1998) https://doi.org/10.1016/S0022-0248(98)00002-5