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Influence of Water Soluble Polymers on Crystallization of 5-Guanosine Monophosphate  

Lee, Min-Kyung (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Choi, Hye-Min (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Kim, Woo-Sik (Department of Chemical Engineering, Kyunghee Univeisity)
Hong, Jong-Pal (KNDT&i Korea NonDestructive Testing Co., Ltd.)
Lee, Jong-Hwi (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Publication Information
Polymer(Korea) / v.33, no.2, 2009 , pp. 124-130 More about this Journal
Abstract
In presence of a polymer, the crystallization of low MW organic materials can be stopped at an intermediary step, where mesocrystals can be identified. A mesocrystal is defined as a superstructure of nanoparticles having polymer-adsorbed crystal faces on the scale of several hundred nanometers to micrometers. This study examined the effects of water soluble polymers and relevant parameters on the formation of guanosine-5'-monophosphate mesocrystals. It was observed in OM and SEM that GMP obtained in a polymer solution had a unique particle morphology different from the typical one of GMP. XRD analysis indicated that the polymer-directed crystallized GMP had a different polymorph of GMP. This result shows that the crystal structure of GMP can be changed by polymers. It was observed in TGA analysis that the polymer-directed crystallized GMP had a different water content, indicating a different type of hydrate.
Keywords
polymorph; water soluble polymer; guanosine-5'-monophosphate; polymer-directed crystallization; mesocrystal;
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